3l13

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Revision as of 15:02, 27 July 2012

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Template:STRUCTURE 3l13

Contents 1 Crystal Structures of Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors 2 About this Structure 3 See Also 4 Reference

Crystal Structures of Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors

Template:ABSTRACT PUBMED 20050669

About this Structure

3l13 is a 1 chain structure of Phosphoinositide 3-Kinases with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Phosphoinositide 3-Kinases

Reference

• Sutherlin DP, Sampath D, Berry M, Castanedo G, Chang Z, Chuckowree I, Dotson J, Folkes A, Friedman L, Goldsmith R, Heffron T, Lee L, Lesnick J, Lewis C, Mathieu S, Nonomiya J, Olivero A, Pang J, Prior WW, Salphati L, Sideris S, Tian Q, Tsui V, Wan NC, Wang S, Wiesmann C, Wong S, Zhu BY. Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer. J Med Chem. 2010 Feb 11;53(3):1086-97. PMID:20050669 doi:10.1021/jm901284w