1hmd
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1hmd.gif|left|200px]] | + | [[Image:1hmd.gif|left|200px]] |
| - | + | ||
| - | '''THE STRUCTURE OF DEOXY AND OXY HEMERYTHRIN AT 2.0 ANGSTROMS RESOLUTION''' | + | {{Structure |
| + | |PDB= 1hmd |SIZE=350|CAPTION= <scene name='initialview01'>1hmd</scene>, resolution 2.0Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> and <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''THE STRUCTURE OF DEOXY AND OXY HEMERYTHRIN AT 2.0 ANGSTROMS RESOLUTION''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1HMD is a [ | + | 1HMD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Themiste_dyscritum Themiste dyscritum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMD OCA]. |
==Reference== | ==Reference== | ||
| - | Structures of deoxy and oxy hemerythrin at 2.0 A resolution., Holmes MA, Le Trong I, Turley S, Sieker LC, Stenkamp RE, J Mol Biol. 1991 Apr 5;218(3):583-93. PMID:[http:// | + | Structures of deoxy and oxy hemerythrin at 2.0 A resolution., Holmes MA, Le Trong I, Turley S, Sieker LC, Stenkamp RE, J Mol Biol. 1991 Apr 5;218(3):583-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2016748 2016748] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Themiste dyscritum]] | [[Category: Themiste dyscritum]] | ||
| Line 22: | Line 31: | ||
[[Category: oxygen transport]] | [[Category: oxygen transport]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:38:57 2008'' |
Revision as of 09:39, 20 March 2008
| |||||||
| , resolution 2.0Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE STRUCTURE OF DEOXY AND OXY HEMERYTHRIN AT 2.0 ANGSTROMS RESOLUTION
Overview
The crystallographic structure analyses of deoxy and oxy hemerythrin have been carried out at 2.0 A resolution to extend the low resolution views of the physiological forms of this oxygen-binding protein. Restrained least-squares refinement has produced molecular models giving R-values of 16.8% for deoxy (41,064 reflections from 10 A to 2.0 A) and 17.3% for oxy hemerythrin (40,413 reflections from 10.0 A to 2.0 A). The protein structure in each derivative is very similar to that of myohemerythrin and the various met forms of hemerythrin. The binuclear complex in each derivative retains an oxygen atom bridging the two iron atoms, but the bond lengths found in deoxy hemerythrin support the idea that, in that form, the bridge is protonated, i.e. the bridging group is a hydroxyl. Dioxygen binds to the pentaco-ordinate iron atom in deoxy hemerythrin in the conversion to oxy hemerythrin. The interatomic distances are consistent with the proposed mechanism where the proton from the bridging group is transferred to the bound dioxygen, stabilizing it in the peroxo oxidation state by forming a hydrogen bond between the peroxy group and the bridging oxygen atom.
About this Structure
1HMD is a Single protein structure of sequence from Themiste dyscritum. Full crystallographic information is available from OCA.
Reference
Structures of deoxy and oxy hemerythrin at 2.0 A resolution., Holmes MA, Le Trong I, Turley S, Sieker LC, Stenkamp RE, J Mol Biol. 1991 Apr 5;218(3):583-93. PMID:2016748
Page seeded by OCA on Thu Mar 20 11:38:57 2008
