1hu3

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[[Image:1hu3.gif|left|200px]]<br /><applet load="1hu3" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1hu3.gif|left|200px]]
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caption="1hu3, resolution 2.37&Aring;" />
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'''MIDDLE DOMAIN OF HUMAN EIF4GII'''<br />
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{{Structure
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|PDB= 1hu3 |SIZE=350|CAPTION= <scene name='initialview01'>1hu3</scene>, resolution 2.37&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''MIDDLE DOMAIN OF HUMAN EIF4GII'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1HU3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HU3 OCA].
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1HU3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HU3 OCA].
==Reference==
==Reference==
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A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery., Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK, Mol Cell. 2001 Jan;7(1):193-203. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11172724 11172724]
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A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery., Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK, Mol Cell. 2001 Jan;7(1):193-203. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11172724 11172724]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: heat repeat]]
[[Category: heat repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:04:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:41:34 2008''

Revision as of 09:41, 20 March 2008

Image:1hu3.gif


PDB ID 1hu3

Drag the structure with the mouse to rotate
, resolution 2.37Å
Coordinates: save as pdb, mmCIF, xml



MIDDLE DOMAIN OF HUMAN EIF4GII


Overview

The X-ray structure of the phylogenetically conserved middle portion of human eukaryotic initiation factor (eIF) 4GII has been determined at 2.4 A resolution, revealing a crescent-shaped domain consisting of ten alpha helices arranged as five HEAT repeats. Together with the ATP-dependent RNA helicase eIF4A, this HEAT domain suffices for 48S ribosomal complex formation with a picornaviral RNA internal ribosome entry site (IRES). Structure-based site-directed mutagenesis was used to identify two adjacent features on the surface of this essential component of the translation initiation machinery that, respectively, bind eIF4A and a picornaviral IRES. The structural and biochemical results provide mechanistic insights into both cap-dependent and cap-independent translation initiation.

About this Structure

1HU3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery., Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK, Mol Cell. 2001 Jan;7(1):193-203. PMID:11172724

Page seeded by OCA on Thu Mar 20 11:41:34 2008

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