1gm5
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | [[1gm5]] is a 4 chain structure | + | [[1gm5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GM5 OCA]. |
==See Also== | ==See Also== | ||
Revision as of 10:14, 20 October 2012
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| 1gm5, resolution 3.24Å () | |||||||||
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| Ligands: | , | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
STRUCTURE OF RECG BOUND TO THREE-WAY DNA JUNCTION
The stalling of DNA replication forks that occurs as a consequence of encountering DNA damage is a critical problem for cells. RecG protein is involved in the processing of stalled replication forks, and acts by reversing the fork past the damage to create a four-way junction that allows template switching and lesion bypass. We have determined the crystal structure of RecG bound to a DNA substrate that mimics a stalled replication fork. The structure not only reveals the elegant mechanism used by the protein to recognize junctions but has also trapped the protein in the initial stage of fork reversal. We propose a mechanism for how forks are processed by RecG to facilitate replication fork restart. In addition, this structure suggests that the mechanism and function of the two largest helicase superfamilies are distinct.
Structural analysis of DNA replication fork reversal by RecG., Singleton MR, Scaife S, Wigley DB, Cell. 2001 Oct 5;107(1):79-89. PMID:11595187
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1gm5 is a 4 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
See Also
Reference
- Singleton MR, Scaife S, Wigley DB. Structural analysis of DNA replication fork reversal by RecG. Cell. 2001 Oct 5;107(1):79-89. PMID:11595187
