2lv3

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'''Unreleased structure'''
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{{STRUCTURE_2lv3| PDB=2lv3 | SCENE= }}
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===Structure-functional characterization of Grx domain of Mus musculus TGR===
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{{ABSTRACT_PUBMED_23300818}}
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The entry 2lv3 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TRXR3_MOUSE TRXR3_MOUSE]] Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components.<ref>PMID:11259642</ref> <ref>PMID:15901730</ref>
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Authors: Dobrovolska, O., Shumilina, E., Gladyshev, V., Dikiy, A.
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==About this Structure==
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[[2lv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LV3 OCA].
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Description: Structure-functional characterization of Grx domain of Mus musculus TGR
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==Reference==
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<ref group="xtra">PMID:023300818</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Thioredoxin-disulfide reductase]]
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[[Category: Dikiy, A.]]
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[[Category: Dobrovolska, O.]]
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[[Category: Gladyshev, V.]]
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[[Category: Shumilina, E.]]
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[[Category: Grx]]
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[[Category: Oxidoreductase]]
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[[Category: Tgr]]

Revision as of 15:54, 19 June 2013

Template:STRUCTURE 2lv3

Contents

Structure-functional characterization of Grx domain of Mus musculus TGR

Template:ABSTRACT PUBMED 23300818

Function

[TRXR3_MOUSE] Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components.[1] [2]

About this Structure

2lv3 is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA.

Reference

  • Dobrovolska O, Shumilina E, Gladyshev VN, Dikiy A. Structural analysis of glutaredoxin domain of Mus musculus thioredoxin glutathione reductase. PLoS One. 2012;7(12):e52914. doi: 10.1371/journal.pone.0052914. Epub 2012 Dec 26. PMID:23300818 doi:10.1371/journal.pone.0052914
  1. ↑ Sun QA, Kirnarsky L, Sherman S, Gladyshev VN. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3673-8. Epub 2001 Mar 20. PMID:11259642 doi:10.1073/pnas.051454398
  2. ↑ Su D, Novoselov SV, Sun QA, Moustafa ME, Zhou Y, Oko R, Hatfield DL, Gladyshev VN. Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation. J Biol Chem. 2005 Jul 15;280(28):26491-8. Epub 2005 May 18. PMID:15901730 doi:M503638200

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