1hxy
From Proteopedia
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| - | [[Image:1hxy.gif|left|200px]] | + | [[Image:1hxy.gif|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II''' | + | {{Structure |
| + | |PDB= 1hxy |SIZE=350|CAPTION= <scene name='initialview01'>1hxy</scene>, resolution 2.6Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HXY is a [ | + | 1HXY is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HXY OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence., Petersson K, Hakansson M, Nilsson H, Forsberg G, Svensson LA, Liljas A, Walse B, EMBO J. 2001 Jul 2;20(13):3306-12. PMID:[http:// | + | Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence., Petersson K, Hakansson M, Nilsson H, Forsberg G, Svensson LA, Liljas A, Walse B, EMBO J. 2001 Jul 2;20(13):3306-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11432818 11432818] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: complex]] | [[Category: complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:42:57 2008'' |
Revision as of 09:42, 20 March 2008
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| , resolution 2.6Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II
Overview
The three-dimensional structure of a bacterial superantigen, Staphylococcus aureus enterotoxin H (SEH), bound to human major histocompatibility complex (MHC) class II (HLA-DR1) has been determined by X-ray crystallography to 2.6 A resolution (1HXY). The superantigen binds on top of HLA-DR1 in a completely different way from earlier co-crystallized superantigens from S.aureus. SEH interacts with high affinity through a zinc ion with the beta1 chain of HLA-DR1 and also with the peptide presented by HLA-DR1. The structure suggests that all superantigens interacting with MHC class II in a zinc-dependent manner present the superantigen in a common way. This suggests a new model for ternary complex formation with the T-cell receptor (TCR), in which a contact between the TCR and the MHC class II is unlikely.
About this Structure
1HXY is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence., Petersson K, Hakansson M, Nilsson H, Forsberg G, Svensson LA, Liljas A, Walse B, EMBO J. 2001 Jul 2;20(13):3306-12. PMID:11432818
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