1hxv
From Proteopedia
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| - | [[Image:1hxv.gif|left|200px]] | + | [[Image:1hxv.gif|left|200px]] |
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| - | '''PPIASE DOMAIN OF THE MYCOPLASMA GENITALIUM TRIGGER FACTOR''' | + | {{Structure |
| + | |PDB= 1hxv |SIZE=350|CAPTION= <scene name='initialview01'>1hxv</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''PPIASE DOMAIN OF THE MYCOPLASMA GENITALIUM TRIGGER FACTOR''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HXV is a [ | + | 1HXV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycoplasma_genitalium Mycoplasma genitalium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HXV OCA]. |
==Reference== | ==Reference== | ||
| - | NMR solution structure and dynamics of the peptidyl-prolyl cis-trans isomerase domain of the trigger factor from Mycoplasma genitalium compared to FK506-binding protein., Vogtherr M, Jacobs DM, Parac TN, Maurer M, Pahl A, Saxena K, Ruterjans H, Griesinger C, Fiebig KM, J Mol Biol. 2002 May 10;318(4):1097-115. PMID:[http:// | + | NMR solution structure and dynamics of the peptidyl-prolyl cis-trans isomerase domain of the trigger factor from Mycoplasma genitalium compared to FK506-binding protein., Vogtherr M, Jacobs DM, Parac TN, Maurer M, Pahl A, Saxena K, Ruterjans H, Griesinger C, Fiebig KM, J Mol Biol. 2002 May 10;318(4):1097-115. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12054805 12054805] |
[[Category: Mycoplasma genitalium]] | [[Category: Mycoplasma genitalium]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: ppiase]] | [[Category: ppiase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:42:56 2008'' |
Revision as of 09:42, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
PPIASE DOMAIN OF THE MYCOPLASMA GENITALIUM TRIGGER FACTOR
Overview
We have solved the solution structure of the peptidyl-prolyl cis-trans isomerase (PPIase) domain of the trigger factor from Mycoplasma genitalium by homo- and heteronuclear NMR spectroscopy. Our results lead to a well-defined structure with a backbone rmsd of 0.23 A. As predicted, the PPIase domain of the trigger factor adopts the FK506 binding protein (FKBP) fold. Furthermore, our NMR relaxation data indicate that the dynamic behavior of the trigger factor PPIase domain and of FKBP are similar. Structural variations when compared to FKBP exist in the flap region and within the bulges of strand 5 of the beta sheet. Although the active-site crevice is similar to that of FKBP, subtle steric variations in this region can explain why FK506 does not bind to the trigger factor. Sequence variability (27% identity) between trigger factor and FKBP results in significant differences in surface charge distribution and the absence of the first strand of the central beta sheet. Our data indicate, however, that this strand may be partially structured as "nascent" beta strand. This makes the trigger factor PPIase domain the most minimal representative of the FKBP like protein family of PPIases.
About this Structure
1HXV is a Single protein structure of sequence from Mycoplasma genitalium. Full crystallographic information is available from OCA.
Reference
NMR solution structure and dynamics of the peptidyl-prolyl cis-trans isomerase domain of the trigger factor from Mycoplasma genitalium compared to FK506-binding protein., Vogtherr M, Jacobs DM, Parac TN, Maurer M, Pahl A, Saxena K, Ruterjans H, Griesinger C, Fiebig KM, J Mol Biol. 2002 May 10;318(4):1097-115. PMID:12054805
Page seeded by OCA on Thu Mar 20 11:42:56 2008
