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4ei5

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[[Image:4ei5.png|left|200px]]
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==Crystal Structure of XV19 TCR in complex with CD1d-sulfatide C24:1==
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<StructureSection load='4ei5' size='340' side='right' caption='[[4ei5]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ei5]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EI5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EI5 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CIS:(15Z)-N-((1S,2R,3E)-2-HYDROXY-1-{[(3-O-SULFO-BETA-D-GALACTOPYRANOSYL)OXY]METHYL}HEPTADEC-3-ENYL)TETRACOS-15-ENAMIDE'>CIS</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2akr|2akr]], [[4ei6|4ei6]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd1d1, Cd1.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ei5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ei5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ei5 RCSB], [http://www.ebi.ac.uk/pdbsum/4ei5 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Natural killer T cells (NKT cells) are divided into type I and type II subsets on the basis of differences in their T cell antigen receptor (TCR) repertoire and CD1d-antigen specificity. Although the mode by which type I NKT cell TCRs recognize CD1d-antigen has been established, how type II NKT cell TCRs engage CD1d-antigen is unknown. Here we provide a basis for how a type II NKT cell TCR, XV19, recognized CD1d-sulfatide. The XV19 TCR bound orthogonally above the A' pocket of CD1d, in contrast to the parallel docking of type I NKT cell TCRs over the F' pocket of CD1d. At the XV19 TCR-CD1d-sulfatide interface, the TCRalpha and TCRbeta chains sat centrally on CD1d, where the malleable CDR3 loops dominated interactions with CD1d-sulfatide. Accordingly, we highlight the diverse mechanisms by which NKT cell TCRs can bind CD1d and account for the distinct antigen specificity of type II NKT cells.
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{{STRUCTURE_4ei5| PDB=4ei5 | SCENE= }}
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Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor.,Patel O, Pellicci DG, Gras S, Sandoval-Romero ML, Uldrich AP, Mallevaey T, Clarke AJ, Le Nours J, Theodossis A, Cardell SL, Gapin L, Godfrey DI, Rossjohn J Nat Immunol. 2012 Jul 22. doi: 10.1038/ni.2372. PMID:22820603<ref>PMID:22820603</ref>
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===Crystal Structure of XV19 TCR in complex with CD1d-sulfatide C24:1===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22820603}}
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==See Also==
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*[[Beta-2 microglobulin|Beta-2 microglobulin]]
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==About this Structure==
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*[[CD1|CD1]]
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[[4ei5]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Mus_musculus,_homo_sapiens Mus musculus, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EI5 OCA].
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*[[T-cell receptor|T-cell receptor]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022820603</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Mus musculus, homo sapiens]]
 
[[Category: Gras, S.]]
[[Category: Gras, S.]]
[[Category: Patel, O.]]
[[Category: Patel, O.]]

Revision as of 06:55, 25 June 2014

Crystal Structure of XV19 TCR in complex with CD1d-sulfatide C24:1

4ei5, resolution 3.10Å

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