1i2z

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[[Image:1i2z.gif|left|200px]]<br /><applet load="1i2z" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1i2z.gif|left|200px]]
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caption="1i2z, resolution 2.8&Aring;" />
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'''E. COLI ENOYL REDUCTASE IN COMPLEX WITH NAD AND BRL-12654'''<br />
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{{Structure
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|PDB= 1i2z |SIZE=350|CAPTION= <scene name='initialview01'>1i2z</scene>, resolution 2.8&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene> and <scene name='pdbligand=654:4-(2-THIENYL)-1-(4-METHYLBENZYL)-1H-IMIDAZOLE'>654</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9]
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|GENE=
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}}
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'''E. COLI ENOYL REDUCTASE IN COMPLEX WITH NAD AND BRL-12654'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1I2Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=NAD:'>NAD</scene> and <scene name='pdbligand=654:'>654</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2Z OCA].
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1I2Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2Z OCA].
==Reference==
==Reference==
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1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)., Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF, Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11514139 11514139]
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1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)., Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF, Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11514139 11514139]
[[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]
[[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: nad]]
[[Category: nad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:07:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:44:49 2008''

Revision as of 09:44, 20 March 2008

Image:1i2z.gif


PDB ID 1i2z

Drag the structure with the mouse to rotate
, resolution 2.8Å
Ligands: and
Activity: [acyl-carrier-protein_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number 1.3.1.9
Coordinates: save as pdb, mmCIF, xml



E. COLI ENOYL REDUCTASE IN COMPLEX WITH NAD AND BRL-12654


Overview

1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI.

About this Structure

1I2Z is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)., Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF, Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5. PMID:11514139 [[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]

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