4f42
From Proteopedia
(Difference between revisions)
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| - | + | {{STRUCTURE_4f42| PDB=4f42 | SCENE= }} | |
| + | ===Neurotrophin p75NTR intracellular domain=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/TNR16_RAT TNR16_RAT]] Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. | ||
| - | + | ==About this Structure== | |
| - | + | [[4f42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F42 OCA]. | |
| - | + | [[Category: Rattus norvegicus]] | |
| + | [[Category: Jiang, T.]] | ||
| + | [[Category: Qu, Q.]] | ||
| + | [[Category: Death domain]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Signalling transduction]] | ||
Revision as of 07:28, 16 May 2013
Neurotrophin p75NTR intracellular domain
Function
[TNR16_RAT] Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
About this Structure
4f42 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
