2cg4

From Proteopedia

Revision as of 15:02, 30 October 2007

STRUCTURE OF E.COLI ASNC

Overview

The Lrp/AsnC family of transcriptional regulatory proteins is found in, both archaea and bacteria. Members of the family influence cellular, metabolism in both a global (Lrp) and specific (AsnC) manner, often in, response to exogenous amino acid effectors. In the present study we have, determined both the first bacterial and the highest resolution structures, for members of the family. Escherichia coli AsnC is a specific gene, regulator whose activity is triggered by asparagine binding. Bacillus, subtilis LrpC is a global regulator involved in chromosome condensation., Our AsnC-asparagine structure is the first for a regulator-effector, complex and is revealed as an octameric disc. Key ligand recognition, residues are identified together with a route for ligand access. The LrpC, structure ... [(full description)]

About this Structure

2CG4 is a [Single protein] structure of sequence from [Escherichia coli] with MG and ASN as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family., Thaw P, Sedelnikova SE, Muranova T, Wiese S, Ayora S, Alonso JC, Brinkman AB, Akerboom J, van der Oost J, Rafferty JB, Nucleic Acids Res. 2006 Mar 9;34(5):1439-49. Print 2006. PMID:16528101

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