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4g31

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[[Image:4g31.jpg|left|200px]]
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{{STRUCTURE_4g31| PDB=4g31 | SCENE= }}
{{STRUCTURE_4g31| PDB=4g31 | SCENE= }}

Revision as of 05:51, 5 September 2012

Image:4g31.png

Template:STRUCTURE 4g31

Crystal Structure of GSK6414 Bound to PERK (R587-R1092, delete A660-T867) at 2.28 A Resolution

Template:ABSTRACT PUBMED 22827572

About this Structure

4g31 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Axten JM, Medina JR, Feng Y, Shu A, Romeril S, Grant S, Li WH, Heerding DA, Minthorn E, Mencken T, Atkins C, Liu Q, Rabindran S, Kumat R, Hong X, Goetz A, Stanley TB, Taylor D, Sigethy S, Tomberlin GH, Hassell A, Shewchuk LM, Gampe R. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-p yrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of PKR-like Endoplasmic Reticulum Kinase (PERK). J Med Chem. 2012 Jul 24. PMID:22827572 doi:10.1021/jm300713s

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OCA

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