This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3r4y
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[ | + | ==Crystal structure of alpha-neoagarobiose hydrolase (ALPHA-NABH) from Saccharophagus degradans 2-40== |
| + | <StructureSection load='3r4y' size='340' side='right' caption='[[3r4y]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3r4y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharophagus_degradans Saccharophagus degradans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R4Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R4Y FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3r4z|3r4z]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sde_2657 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=86304 Saccharophagus degradans])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r4y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r4y RCSB], [http://www.ebi.ac.uk/pdbsum/3r4y PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | In agarolytic microorganisms, alpha-neoagarobiose hydrolase (NABH) is an essential enzyme to metabolize agar because it converts alpha-neoagarobiose (O-3,6-anhydro-alpha-l-galactopyranosyl-(1,3)-d-galactose) into fermentable monosaccharides (d-galactose and 3,6-anhydro-l-galactose) in the agarolytic pathway. NABH can be divided into two biological classes by its cellular location. Here, we describe a structure and function of cytosolic NABH from Saccharophagus degradans 2-40 in a native protein and d-galactose complex determined at 2.0 and 1.55 A, respectively. The overall fold is organized in an N-terminal helical extension and a C-terminal five-bladed beta-propeller catalytic domain. The structure of the enzyme-ligand (d-galactose) complex predicts a +1 subsite in the substrate binding pocket. The structural features may provide insights for the evolution and classification of NABH in agarolytic pathways. | ||
| - | + | Crystal structure of a key enzyme in the agarolytic pathway, alpha-neoagarobiose hydrolase from Saccharophagus degradans 2-40.,Ha SC, Lee S, Lee J, Kim HT, Ko HJ, Kim KH, Choi IG Biochem Biophys Res Commun. 2011 Aug 26;412(2):238-44. Epub 2011 Jul 23. PMID:21810409<ref>PMID:21810409</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Saccharophagus degradans]] | [[Category: Saccharophagus degradans]] | ||
| - | [[Category: Bang, W G | + | [[Category: Bang, W G]] |
| - | [[Category: Choi, I G | + | [[Category: Choi, I G]] |
| - | [[Category: Ha, S C | + | [[Category: Ha, S C]] |
| - | [[Category: Kim, K H | + | [[Category: Kim, K H]] |
| - | [[Category: Kim, S H | + | [[Category: Kim, S H]] |
| - | [[Category: Lee, J Y | + | [[Category: Lee, J Y]] |
| - | [[Category: Lee, S | + | [[Category: Lee, S]] |
| - | [[Category: Shin, D H | + | [[Category: Shin, D H]] |
[[Category: 6-anhydro-l-galactose]] | [[Category: 6-anhydro-l-galactose]] | ||
[[Category: Agar metabolism]] | [[Category: Agar metabolism]] | ||
Revision as of 23:09, 3 January 2015
Crystal structure of alpha-neoagarobiose hydrolase (ALPHA-NABH) from Saccharophagus degradans 2-40
| |||||||||||
