This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ias

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ias.gif|left|200px]]<br /><applet load="1ias" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1ias.gif|left|200px]]
-
caption="1ias, resolution 2.9&Aring;" />
+
 
-
'''CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12'''<br />
+
{{Structure
 +
|PDB= 1ias |SIZE=350|CAPTION= <scene name='initialview01'>1ias</scene>, resolution 2.9&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
 +
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]
 +
|GENE=
 +
}}
 +
 
 +
'''CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==Disease==
==Disease==
-
Known diseases associated with this structure: Aortic aneurysm, familial thoracic 5 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190181 190181]], Furlong syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190181 190181]], Loeys-Dietz syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190181 190181]]
+
Known diseases associated with this structure: Loeys-Dietz syndrome, type 1A OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190181 190181]], Loeys-Dietz syndrome, type 2A OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190181 190181]]
==About this Structure==
==About this Structure==
-
1IAS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IAS OCA].
+
1IAS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IAS OCA].
==Reference==
==Reference==
-
The TGF beta receptor activation process: an inhibitor- to substrate-binding switch., Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massague J, Mol Cell. 2001 Sep;8(3):671-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11583628 11583628]
+
The TGF beta receptor activation process: an inhibitor- to substrate-binding switch., Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massague J, Mol Cell. 2001 Sep;8(3):671-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11583628 11583628]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
Line 27: Line 36:
[[Category: tgf-beta receptor]]
[[Category: tgf-beta receptor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:09:51 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:47:50 2008''

Revision as of 09:47, 20 March 2008

Image:1ias.gif


PDB ID 1ias

Drag the structure with the mouse to rotate
, resolution 2.9Å
Ligands:
Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Coordinates: save as pdb, mmCIF, xml



CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12


Contents

Overview

The type I TGF beta receptor (T beta R-I) is activated by phosphorylation of the GS region, a conserved juxtamembrane segment located just N-terminal to the kinase domain. We have studied the molecular mechanism of receptor activation using a homogeneously tetraphosphorylated form of T beta R-I, prepared using protein semisynthesis. Phosphorylation of the GS region dramatically enhances the specificity of T beta R-I for the critical C-terminal serines of Smad2. In addition, tetraphosphorylated T beta R-I is bound specifically by Smad2 in a phosphorylation-dependent manner and is no longer recognized by the inhibitory protein FKBP12. Thus, phosphorylation activates T beta R-I by switching the GS region from a binding site for an inhibitor into a binding surface for substrate. Our observations suggest that phosphoserine/phosphothreonine-dependent localization is a key feature of the T beta R-I/Smad activation process.

Disease

Known diseases associated with this structure: Loeys-Dietz syndrome, type 1A OMIM:[190181], Loeys-Dietz syndrome, type 2A OMIM:[190181]

About this Structure

1IAS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The TGF beta receptor activation process: an inhibitor- to substrate-binding switch., Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massague J, Mol Cell. 2001 Sep;8(3):671-82. PMID:11583628

Page seeded by OCA on Thu Mar 20 11:47:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ias"
Personal tools