1ic9

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[[Image:1ic9.gif|left|200px]]<br /><applet load="1ic9" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ic9.gif|left|200px]]
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caption="1ic9" />
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'''NMR SOLUTION STRUCTURE OF THE DESIGNED BETA-SHEET MINI-PROTEIN TH10AOX'''<br />
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{{Structure
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|PDB= 1ic9 |SIZE=350|CAPTION= <scene name='initialview01'>1ic9</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''NMR SOLUTION STRUCTURE OF THE DESIGNED BETA-SHEET MINI-PROTEIN TH10AOX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1IC9 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC9 OCA].
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1IC9 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC9 OCA].
==Reference==
==Reference==
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Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11373623 11373623]
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Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11373623 11373623]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Imperiali, B.]]
[[Category: Imperiali, B.]]
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[[Category: three stranded antiparallel beta-sheet mini-protein motif de novo protein design]]
[[Category: three stranded antiparallel beta-sheet mini-protein motif de novo protein design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:10:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:48:31 2008''

Revision as of 09:48, 20 March 2008

Image:1ic9.gif


PDB ID 1ic9

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Coordinates: save as pdb, mmCIF, xml



NMR SOLUTION STRUCTURE OF THE DESIGNED BETA-SHEET MINI-PROTEIN TH10AOX


Overview

Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.

About this Structure

1IC9 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:11373623

Page seeded by OCA on Thu Mar 20 11:48:31 2008

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