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1d32

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[[Image:1d32.png|left|200px]]
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==DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX==
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<StructureSection load='1d32' size='340' side='right' caption='[[1d32]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1d32]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D32 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIT:DITERCALINIUM'>DIT</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d32 RCSB], [http://www.ebi.ac.uk/pdbsum/1d32 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ditercalinium is a synthetic anticancer drug that binds to DNA by bis-intercalation and activates DNA repair processes. In prokaryotes, noncovalent DNA-ditercalinium complexes are incorrectly recognized by the uvrABC repair system as covalent lesions on DNA. In eukaryotes, mitochondrial DNA is degraded by excess and futile DNA repair. Using x-ray crystallography, we have determined, to 1.7 A resolution, the three-dimensional structure of a complex of ditercalinium bound to the double-stranded DNA fragment [d(CGCG)]2. The DNA in the complex with ditercalinium is kinked (by 15 degrees) and severely unwound (by 36 degrees) with exceptionally wide major and minor grooves. Recognition of the DNA-ditercalinium complex by uvrABC in prokaryotes, and by mitochondrial DNA repair systems in eukaryotes, might be related to drug-induced distortion of the DNA helix.
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{{STRUCTURE_1d32| PDB=1d32 | SCENE= }}
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Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex.,Gao Q, Williams LD, Egli M, Rabinovich D, Chen SL, Quigley GJ, Rich A Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2422-6. PMID:2006181<ref>PMID:2006181</ref>
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===DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_2006181}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1d32]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D32 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:002006181</ref><references group="xtra"/>
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[[Category: Chen, S L.]]
[[Category: Chen, S L.]]
[[Category: Egli, M.]]
[[Category: Egli, M.]]

Revision as of 05:44, 8 June 2014

DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX

1d32, resolution 1.70Å

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