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1v6r

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[[Image:1v6r.png|left|200px]]
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==Solution Structure of Endothelin-1 with its C-terminal Folding==
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<StructureSection load='1v6r' size='340' side='right' caption='[[1v6r]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1v6r]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V6R FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v6r RCSB], [http://www.ebi.ac.uk/pdbsum/1v6r PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Distributed computing has been implemented to the solution structure determination of endothelin-1 to evaluate efficiency of the method for NMR constraint-based structure calculations. A key target of the investigation was determination of the C-terminal folding of the peptide, which had been dispersed in previous studies of NMR, despite its pharmacological significances. With use of tens of thousands of random initial structures to explore the conformational space comprehensively, we determined high-resolution structures with good convergences of C-terminal as well as previously defined N-terminal structures. The previous studies had missed the C-terminal convergence because of initial structure dependencies trapped in localized folding of the N-terminal region, which are strongly constricted by two disulfide bonds.
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{{STRUCTURE_1v6r| PDB=1v6r | SCENE= }}
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Distributed computing and NMR constraint-based high-resolution structure determination: applied for bioactive Peptide endothelin-1 to determine C-terminal folding.,Takashima H, Mimura N, Ohkubo T, Yoshida T, Tamaoki H, Kobayashi Y J Am Chem Soc. 2004 Apr 14;126(14):4504-5. PMID:15070353<ref>PMID:15070353</ref>
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===Solution Structure of Endothelin-1 with its C-terminal Folding===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15070353}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1v6r]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6R OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015070353</ref><references group="xtra"/>
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[[Category: Kobayashi, Y.]]
[[Category: Kobayashi, Y.]]
[[Category: Mimura, N.]]
[[Category: Mimura, N.]]

Revision as of 06:54, 9 June 2014

Solution Structure of Endothelin-1 with its C-terminal Folding

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