1jbf

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[[Image:1jbf.png|left|200px]]
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==Hairpin Peptide that Inhibits IgE Activity by Binding to the High Affinity IgE Receptor==
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<StructureSection load='1jbf' size='340' side='right' caption='[[1jbf]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jbf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JBF FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jbf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jbf RCSB], [http://www.ebi.ac.uk/pdbsum/1jbf PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A family of structured peptides that bind to FcepsilonRIalpha, the alpha-chain of the high-affinity receptor for IgE, has been identified. Binding selections using FcepsilonRIalpha and polyvalent peptide-phage libraries yielded a dominant 18-residue peptide-phage clone, as well as related sequences that did not resemble fragments of IgE. Synthetic peptides based on these sequences inhibited IgE binding to its receptor, and were found by NMR analysis to adopt a stable beta-hairpin structure in solution. Optimized peptides with micromolar receptor affinity exhibited high stability in biological fluids and inhibited cellular histamine release in an in vitro bioassay of IgE activity. The structure-activity relationships of these peptides, which are less than 1% of the size of IgE, suggest an overlap between their binding site and that of IgE on FcepsilonRI. Thus, the peptides demonstrate that blocking a small epitope on this receptor chain is sufficient to block IgE activity. Such structured peptides represent a possible starting point for the design of novel antagonists, and offer the potential for testing in vivo a new approach for treating allergic disease.
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{{STRUCTURE_1jbf| PDB=1jbf | SCENE= }}
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A novel family of hairpin peptides that inhibit IgE activity by binding to the high-affinity IgE receptor.,Nakamura GR, Starovasnik MA, Reynolds ME, Lowman HB Biochemistry. 2001 Aug 21;40(33):9828-35. PMID:11502176<ref>PMID:11502176</ref>
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===Hairpin Peptide that Inhibits IgE Activity by Binding to the High Affinity IgE Receptor===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_11502176}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1jbf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBF OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:011502176</ref><references group="xtra"/>
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[[Category: Lowman, H B.]]
[[Category: Lowman, H B.]]
[[Category: Nakamura, G R.]]
[[Category: Nakamura, G R.]]

Revision as of 05:51, 8 June 2014

Hairpin Peptide that Inhibits IgE Activity by Binding to the High Affinity IgE Receptor

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