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1ihm
From Proteopedia
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| - | [[Image:1ihm.gif|left|200px]] | + | [[Image:1ihm.gif|left|200px]] |
| - | + | ||
| - | '''CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID''' | + | {{Structure |
| + | |PDB= 1ihm |SIZE=350|CAPTION= <scene name='initialview01'>1ihm</scene>, resolution 3.4Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1IHM is a [ | + | 1IHM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHM OCA]. |
==Reference== | ==Reference== | ||
| - | X-ray crystallographic structure of the Norwalk virus capsid., Prasad BV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK, Science. 1999 Oct 8;286(5438):287-90. PMID:[http:// | + | X-ray crystallographic structure of the Norwalk virus capsid., Prasad BV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK, Science. 1999 Oct 8;286(5438):287-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10514371 10514371] |
[[Category: Norwalk virus]] | [[Category: Norwalk virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: t=3 icosahedral capsid]] | [[Category: t=3 icosahedral capsid]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:50:27 2008'' |
Revision as of 09:50, 20 March 2008
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| , resolution 3.4Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID
Overview
Norwalk virus, a noncultivatable human calicivirus, is the major cause of epidemic gastroenteritis in humans. The first x-ray structure of a calicivirus capsid, which consists of 180 copies of a single protein, has been determined by phase extension from a low-resolution electron microscopy structure. The capsid protein has a protruding (P) domain connected by a flexible hinge to a shell (S) domain that has a classical eight-stranded beta-sandwich motif. The structure of the P domain is unlike that of any other viral protein with a subdomain exhibiting a fold similar to that of the second domain in the eukaryotic translation elongation factor-Tu. This subdomain, located at the exterior of the capsid, has the largest sequence variation among Norwalk-like human caliciviruses and is likely to contain the determinants of strain specificity and cell binding.
About this Structure
1IHM is a Single protein structure of sequence from Norwalk virus. Full crystallographic information is available from OCA.
Reference
X-ray crystallographic structure of the Norwalk virus capsid., Prasad BV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK, Science. 1999 Oct 8;286(5438):287-90. PMID:10514371
Page seeded by OCA on Thu Mar 20 11:50:27 2008
