1z64

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[[Image:1z64.png|left|200px]]
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==NMR Solution Structure of Pleurocidin in DPC Micelles==
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<StructureSection load='1z64' size='340' side='right' caption='[[1z64]], [[NMR_Ensembles_of_Models | 11 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1z64]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudopleuronectes_americanus Pseudopleuronectes americanus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z64 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z64 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z64 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z64 RCSB], [http://www.ebi.ac.uk/pdbsum/1z64 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pleurocidin is an antimicrobial peptide that was isolated from the mucus membranes of winter flounder (Pseudopleuronectes americanus) and contributes to the initial stages of defense against bacterial infection. From NMR structural studies with the uniformly (15)N-labeled peptide, a structure of pleurocidin was determined to be in a random coil conformation in aqueous solution whereas it assumes an alpha-helical structure in TFE and in dodecylphosphocholine (DPC) micelles. From (15)N relaxation studies, the helix is a rigid structure in the membrane-mimicking environment. Strong NOESY cross-peaks from the pleurocidin to the aliphatic chain on DPC confirm that pleurocidin is contained within the DPC micelle and not associated with the surface of the micelle. From diffusion studies it was determined that each micelle contains at least two pleurocidin molecules.
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{{STRUCTURE_1z64| PDB=1z64 | SCENE= }}
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Structural characterization of the antimicrobial peptide pleurocidin from winter flounder.,Syvitski RT, Burton I, Mattatall NR, Douglas SE, Jakeman DL Biochemistry. 2005 May 17;44(19):7282-93. PMID:15882067<ref>PMID:15882067</ref>
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===NMR Solution Structure of Pleurocidin in DPC Micelles===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15882067}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1z64]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudopleuronectes_americanus Pseudopleuronectes americanus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z64 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015882067</ref><references group="xtra"/>
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[[Category: Pseudopleuronectes americanus]]
[[Category: Pseudopleuronectes americanus]]
[[Category: Burton, I.]]
[[Category: Burton, I.]]

Revision as of 07:03, 9 June 2014

NMR Solution Structure of Pleurocidin in DPC Micelles

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