1ijl
From Proteopedia
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- | [[Image:1ijl.jpg|left|200px]] | + | [[Image:1ijl.jpg|left|200px]] |
- | + | ||
- | '''Crystal structure of acidic phospholipase A2 from deinagkistrodon acutus''' | + | {{Structure |
+ | |PDB= 1ijl |SIZE=350|CAPTION= <scene name='initialview01'>1ijl</scene>, resolution 2.6Å | ||
+ | |SITE= | ||
+ | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | ||
+ | |ACTIVITY= [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] | ||
+ | |GENE= | ||
+ | }} | ||
+ | |||
+ | '''Crystal structure of acidic phospholipase A2 from deinagkistrodon acutus''' | ||
+ | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
- | 1IJL is a [ | + | 1IJL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinagkistrodon_acutus Deinagkistrodon acutus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJL OCA]. |
==Reference== | ==Reference== | ||
- | Structure of an acidic phospholipase A2 from the venom of Deinagkistrodon acutus., Gu L, Zhang H, Song S, Zhou Y, Lin Z, Acta Crystallogr D Biol Crystallogr. 2002 Jan;58(Pt 1):104-10. Epub 2001, Dec 21. PMID:[http:// | + | Structure of an acidic phospholipase A2 from the venom of Deinagkistrodon acutus., Gu L, Zhang H, Song S, Zhou Y, Lin Z, Acta Crystallogr D Biol Crystallogr. 2002 Jan;58(Pt 1):104-10. Epub 2001, Dec 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11752784 11752784] |
[[Category: Deinagkistrodon acutus]] | [[Category: Deinagkistrodon acutus]] | ||
[[Category: Phospholipase A(2)]] | [[Category: Phospholipase A(2)]] | ||
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[[Category: three long helix]] | [[Category: three long helix]] | ||
- | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:51:11 2008'' |
Revision as of 09:51, 20 March 2008
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, resolution 2.6Å | |||||||
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Ligands: | and | ||||||
Activity: | Phospholipase A(2), with EC number 3.1.1.4 | ||||||
Coordinates: | save as pdb, mmCIF, xml |
Crystal structure of acidic phospholipase A2 from deinagkistrodon acutus
Overview
An acidic phospholipase A(2) was purified from Deinagkistrodon acutus (Agkistrodon acutus) which displays an inhibitory effect on platelet aggregation. The three-dimensional structure of the enzyme was determined by molecular replacement at 2.6 A resolution with a crystallographic R factor of 18.40% (R(free) = 22.50%) and reasonable stereochemistry. Two molecules in the asymmetric unit form a dimer and the dimer formation accompanies a significant conformational adaptation of segment 14-23, a constituent of the 'interface recognition site' (IRS). This probably reflects the inherent structural flexibility of the IRS. The possible expansion of the site for inhibiting platelet aggregation as proposed previously [Wang et al. (1996), J. Mol. Biol. 255, 669-676] is discussed.
About this Structure
1IJL is a Single protein structure of sequence from Deinagkistrodon acutus. Full crystallographic information is available from OCA.
Reference
Structure of an acidic phospholipase A2 from the venom of Deinagkistrodon acutus., Gu L, Zhang H, Song S, Zhou Y, Lin Z, Acta Crystallogr D Biol Crystallogr. 2002 Jan;58(Pt 1):104-10. Epub 2001, Dec 21. PMID:11752784
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