1ik3

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[[Image:1ik3.jpg|left|200px]]<br /><applet load="1ik3" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ik3.jpg|left|200px]]
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caption="1ik3, resolution 2.0&Aring;" />
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'''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID'''<br />
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{{Structure
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|PDB= 1ik3 |SIZE=350|CAPTION= <scene name='initialview01'>1ik3</scene>, resolution 2.0&Aring;
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|SITE= <scene name='pdbsite=FE3:Fe+(Fe+3)+Active+Site'>FE3</scene>
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|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=13S:13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC+ACID'>13S</scene>, <scene name='pdbligand=13R:13(R)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC+ACID'>13R</scene>, <scene name='pdbligand=9OH:(TRANS-12,13-EPOXY)-9-HYDROXY-10(E)-OCTADECENOIC+ACID'>9OH</scene> and <scene name='pdbligand=11O:(TRANS-12,13-EPOXY)-11-HYDROXY-9(Z)-OCTADECENOIC ACID'>11O</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12]
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|GENE=
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}}
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'''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1IK3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Glycine_max Glycine max] with <scene name='pdbligand=FE:'>FE</scene>, <scene name='pdbligand=13S:'>13S</scene>, <scene name='pdbligand=13R:'>13R</scene>, <scene name='pdbligand=9OH:'>9OH</scene> and <scene name='pdbligand=11O:'>11O</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12] Known structural/functional Site: <scene name='pdbsite=FE3:Fe+(Fe+3)+Active+Site'>FE3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IK3 OCA].
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1IK3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Glycine_max Glycine max]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IK3 OCA].
==Reference==
==Reference==
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Three-dimensional structure of a purple lipoxygenase., Skrzypczak-Jankun E, Bross RA, Carroll RT, Dunham WR, Funk MO Jr, J Am Chem Soc. 2001 Nov 7;123(44):10814-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11686682 11686682]
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Three-dimensional structure of a purple lipoxygenase., Skrzypczak-Jankun E, Bross RA, Carroll RT, Dunham WR, Funk MO Jr, J Am Chem Soc. 2001 Nov 7;123(44):10814-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11686682 11686682]
[[Category: Glycine max]]
[[Category: Glycine max]]
[[Category: Lipoxygenase]]
[[Category: Lipoxygenase]]
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[[Category: purple lipoxygenase]]
[[Category: purple lipoxygenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:12:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:51:26 2008''

Revision as of 09:51, 20 March 2008

Image:1ik3.jpg


PDB ID 1ik3

Drag the structure with the mouse to rotate
, resolution 2.0Å
Sites:
Ligands: , , , and
Activity: Lipoxygenase, with EC number 1.13.11.12
Coordinates: save as pdb, mmCIF, xml



LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID


Overview

Polyunsaturated fatty acid metabolism is governed primarily by two enzymes, prostaglandin H synthase and lipoxygenase. The crystal structure of the metastable product-oxidized purple form of soybean lipoxygenase-3 was determined at 2.0 A resolution. The data reveal that the chromophore corresponds to an iron-peroxide complex, a potential intermediate in the catalyzed reaction. A significant alteration of the iron site accompanies the formation of the complex. The structure, the first for a fatty acid-lipoxygenase complex, also reveals an unexpected mode of binding, and identifies amino acid residues that may play significant roles in catalysis, regio- and stereoselectivity.

About this Structure

1IK3 is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of a purple lipoxygenase., Skrzypczak-Jankun E, Bross RA, Carroll RT, Dunham WR, Funk MO Jr, J Am Chem Soc. 2001 Nov 7;123(44):10814-20. PMID:11686682

Page seeded by OCA on Thu Mar 20 11:51:26 2008

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