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2az2

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[[Image:2az2.png|left|200px]]
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==Flock House virus B2-dsRNA Complex (P4122)==
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<StructureSection load='2az2' size='340' side='right' caption='[[2az2]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2az2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Flock_house_virus Flock house virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AZ2 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2az0|2az0]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12287 Flock house virus])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2az2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2az2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2az2 RCSB], [http://www.ebi.ac.uk/pdbsum/2az2 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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As a counter-defense against antiviral RNA silencing during infection, the insect Flock House virus (FHV) expresses the silencing suppressor protein B2. Biochemical experiments show that B2 binds to double-stranded RNA (dsRNA) without regard to length and inhibits cleavage of dsRNA by Dicer in vitro. A cocrystal structure reveals that a B2 dimer forms a four-helix bundle that binds to one face of an A-form RNA duplex independently of sequence. These results suggest that B2 blocks both cleavage of the FHV genome by Dicer and incorporation of FHV small interfering RNAs into the RNA-induced silencing complex.
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{{STRUCTURE_2az2| PDB=2az2 | SCENE= }}
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Dual modes of RNA-silencing suppression by Flock House virus protein B2.,Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR Nat Struct Mol Biol. 2005 Nov;12(11):952-7. PMID:16228003<ref>PMID:16228003</ref>
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===Flock House virus B2-dsRNA Complex (P4122)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16228003}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2az2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Flock_house_virus Flock house virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZ2 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:016228003</ref><references group="xtra"/>
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[[Category: Flock house virus]]
[[Category: Flock house virus]]
[[Category: Chao, J A.]]
[[Category: Chao, J A.]]

Revision as of 07:06, 9 June 2014

Flock House virus B2-dsRNA Complex (P4122)

2az2, resolution 2.60Å

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