1z3f

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[[Image:1z3f.png|left|200px]]
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==Structure of ellipticine in complex with a 6-bp DNA==
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<StructureSection load='1z3f' size='340' side='right' caption='[[1z3f]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1z3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z3F FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EL:ELLIPTICINE'>EL</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z3f RCSB], [http://www.ebi.ac.uk/pdbsum/1z3f PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ellipticine is a natural plant product that has been found to be a powerful anticancer drug. Although still unclear, its mechanism of action is considered to be mainly based on DNA intercalation and/or the inhibition of topoisomerase II. Many experimental data suggest an intercalation based on stacking interactions along the major base-pair axis, but alternative binding modes have been proposed, in particular for ellipticine derivatives. The 1.5 A resolution structure of ellipticine complexed to a 6 bp oligonucleotide unveils its mode of binding and enables a detailed analysis of the distorting effects of the drug on the DNA.
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{{STRUCTURE_1z3f| PDB=1z3f | SCENE= }}
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The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs.,Canals A, Purciolas M, Aymami J, Coll M Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):1009-12. Epub 2005, Jun 24. PMID:15983425<ref>PMID:15983425</ref>
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===Structure of ellipticine in complex with a 6-bp DNA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15983425}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1z3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3F OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015983425</ref><references group="xtra"/>
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[[Category: Aymami, J.]]
[[Category: Aymami, J.]]
[[Category: Canals, A.]]
[[Category: Canals, A.]]

Revision as of 07:09, 9 June 2014

Structure of ellipticine in complex with a 6-bp DNA

1z3f, resolution 1.50Å

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