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1k1f

From Proteopedia

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[[Image:1k1f.png|left|200px]]
 
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{{STRUCTURE_1k1f| PDB=1k1f | SCENE= }}
{{STRUCTURE_1k1f| PDB=1k1f | SCENE= }}
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===Structure of the Bcr-Abl Oncoprotein Oligomerization domain===
===Structure of the Bcr-Abl Oncoprotein Oligomerization domain===
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{{ABSTRACT_PUBMED_11780146}}
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{{ABSTRACT_PUBMED_11780146}}
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==Disease==
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[[http://www.uniprot.org/uniprot/BCR_HUMAN BCR_HUMAN]] Note=A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
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==Function==
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[[http://www.uniprot.org/uniprot/BCR_HUMAN BCR_HUMAN]] GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.<ref>PMID:1903516</ref><ref>PMID:1657398</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:011780146</ref><references group="xtra"/>
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<ref group="xtra">PMID:011780146</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ghaffari, S.]]
[[Category: Ghaffari, S.]]

Revision as of 23:40, 24 March 2013

Template:STRUCTURE 1k1f

Contents

Structure of the Bcr-Abl Oncoprotein Oligomerization domain

Template:ABSTRACT PUBMED 11780146

Disease

[BCR_HUMAN] Note=A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

Function

[BCR_HUMAN] GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.[1][2]

About this Structure

1k1f is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Zhao X, Ghaffari S, Lodish H, Malashkevich VN, Kim PS. Structure of the Bcr-Abl oncoprotein oligomerization domain. Nat Struct Biol. 2002 Feb;9(2):117-20. PMID:11780146 doi:10.1038/nsb747
  1. ↑ Diekmann D, Brill S, Garrett MD, Totty N, Hsuan J, Monfries C, Hall C, Lim L, Hall A. Bcr encodes a GTPase-activating protein for p21rac. Nature. 1991 May 30;351(6325):400-2. PMID:1903516 doi:http://dx.doi.org/10.1038/351400a0
  2. ↑ Maru Y, Witte ON. The BCR gene encodes a novel serine/threonine kinase activity within a single exon. Cell. 1991 Nov 1;67(3):459-68. PMID:1657398

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