2gku

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[[Image:2gku.png|left|200px]]
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==Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures==
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<StructureSection load='2gku' size='340' side='right' caption='[[2gku]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2gku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GKU FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[143d|143d]], [[186d|186d]], [[1k8p|1k8p]], [[2aqy|2aqy]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gku RCSB], [http://www.ebi.ac.uk/pdbsum/2gku PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.
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{{STRUCTURE_2gku| PDB=2gku | SCENE= }}
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Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold.,Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:16866556<ref>PMID:16866556</ref>
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===Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16866556}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2gku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:016866556</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kuryavyi, V V.]]
[[Category: Kuryavyi, V V.]]

Revision as of 06:47, 9 June 2014

Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures

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