2hx6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2hx6" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:2hx6.png|left|200px]]
+
==Solution structure analysis of the phage T4 endoribonuclease RegB==
 +
<StructureSection load='2hx6' size='340' side='right' caption='[[2hx6]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2hx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HX6 FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">regB, 61.9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])</td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2hx6 PDBsum]</span></td></tr>
 +
<table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The RegB endoribonuclease participates in the bacteriophage T4 life cycle by favoring early messenger RNA breakdown. RegB specifically cleaves GGAG sequences found in intergenic regions, mainly in translation initiation sites. Its activity is very low but can be enhanced up to 100-fold by the ribosomal 30 S subunit or by ribosomal protein S1. RegB has no significant sequence homology to any known protein. Here we used NMR to solve the structure of RegB and map its interactions with two RNA substrates. We also generated a collection of mutants affected in RegB function. Our results show that, despite the absence of any sequence homology, RegB has structural similarities with two Escherichia coli ribonucleases involved in mRNA inactivation on translating ribosomes: YoeB and RelE. Although these ribonucleases have different catalytic sites, we propose that RegB is a new member of the RelE/YoeB structural and functional family of ribonucleases specialized in mRNA inactivation within the ribosome.
-
{{STRUCTURE_2hx6| PDB=2hx6 | SCENE= }}
+
Structural and functional studies of RegB, a new member of a family of sequence-specific ribonucleases involved in mRNA inactivation on the ribosome.,Odaert B, Saida F, Aliprandi P, Durand S, Crechet JB, Guerois R, Laalami S, Uzan M, Bontems F J Biol Chem. 2007 Jan 19;282(3):2019-28. Epub 2006 Oct 17. PMID:17046813<ref>PMID:17046813</ref>
-
===Solution structure analysis of the phage T4 endoribonuclease RegB===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_17046813}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[2hx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HX6 OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:017046813</ref><references group="xtra"/>
+
[[Category: Enterobacteria phage t4]]
[[Category: Enterobacteria phage t4]]
[[Category: Bontems, F.]]
[[Category: Bontems, F.]]

Revision as of 07:01, 9 June 2014

Solution structure analysis of the phage T4 endoribonuclease RegB

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hx6"
Views
Personal tools
Navigation
Toolbox