2fqn

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[[Image:2fqn.png|left|200px]]
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==Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site==
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<StructureSection load='2fqn' size='340' side='right' caption='[[2fqn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2fqn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FQN FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fqn RCSB], [http://www.ebi.ac.uk/pdbsum/2fqn PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The decoding A site of the small ribosomal subunit is an RNA molecular switch, which monitors codon-anticodon interactions to guarantee translation fidelity. We have solved the crystal structure of an RNA fragment containing two Homo sapiens cytoplasmic A sites. Each of the two A sites presents a different conformational state. In one state, adenines A1492 and A1493 are fully bulged-out with C1409 forming a wobble-like pair to A1491. In the second state, adenines A1492 and A1493 form non-Watson-Crick pairs with C1409 and G1408, respectively while A1491 bulges out. The first state of the eukaryotic A site is, thus, basically the same as in the bacterial A site with bulging A1492 and A1493. It is the state used for recognition of the codon/anticodon complex. On the contrary, the second state of the H.sapiens cytoplasmic A site is drastically different from any of those observed for the bacterial A site without bulging A1492 and A1493.
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{{STRUCTURE_2fqn| PDB=2fqn | SCENE= }}
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Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site.,Kondo J, Urzhumtsev A, Westhof E Nucleic Acids Res. 2006 Feb 1;34(2):676-85. Print 2006. PMID:16452297<ref>PMID:16452297</ref>
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===Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16452297}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2fqn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FQN OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:016452297</ref><references group="xtra"/>
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[[Category: Kondo, J.]]
[[Category: Kondo, J.]]
[[Category: Urzhumtsev, A.]]
[[Category: Urzhumtsev, A.]]

Revision as of 07:03, 9 June 2014

Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site

2fqn, resolution 2.30Å

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