1au6

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[[Image:1au6.png|left|200px]]
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==SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE==
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<StructureSection load='1au6' size='340' side='right' caption='[[1au6]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1au6]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AU6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AU6 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BPT:BIS(TRANS-PLATINUM+ETHYLENEDIAMINE+DIAMINE+CHLORO)COMPLEX'>BPT</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1au6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1au6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1au6 RCSB], [http://www.ebi.ac.uk/pdbsum/1au6 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The bifunctional platinum compound, [(trans-PtCI(NH)3)2)2(H2N(CH2)4NH2)]2+, forms a stable adduct with the self-complementary DNA oligomer CATGCATG, with the two platinum atoms coordinated at the N7 positions of the two symmetrical G4 nucleotides. The NMR-derived structure shows that the DNA octamer forms a novel hairpin structure with the platinated G4 residue adopting a syn conformation and the guanine base in the minor groove. Two such hairpins stack end-over-end and are linked together by the butanediamine tether to form a dumbbell structure. Such unusual structural distortion is different from that of the anticancer drug cisplatin-DNA adduct and may provide clues to explain the distinct biological activities of the two compounds.
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{{STRUCTURE_1au6| PDB=1au6 | SCENE= }}
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A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA.,Yang D, van Boom SS, Reedijk J, van Boom JH, Farrell N, Wang AH Nat Struct Biol. 1995 Jul;2(7):577-8. PMID:7664126<ref>PMID:7664126</ref>
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===SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_7664126}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1au6]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AU6 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:007664126</ref><references group="xtra"/>
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[[Category: Boom, J H.Van.]]
[[Category: Boom, J H.Van.]]
[[Category: Boom, S S.G E.Van.]]
[[Category: Boom, S S.G E.Van.]]

Revision as of 05:42, 8 June 2014

SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE

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