1iu1

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[[Image:1iu1.jpg|left|200px]]<br /><applet load="1iu1" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1iu1.jpg|left|200px]]
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caption="1iu1, resolution 1.80&Aring;" />
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'''Crystal structure of human gamma1-adaptin ear domain'''<br />
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{{Structure
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|PDB= 1iu1 |SIZE=350|CAPTION= <scene name='initialview01'>1iu1</scene>, resolution 1.80&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of human gamma1-adaptin ear domain'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1IU1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IU1 OCA].
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1IU1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IU1 OCA].
==Reference==
==Reference==
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Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain., Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S, Nat Struct Biol. 2002 Jul;9(7):527-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12042876 12042876]
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Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain., Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S, Nat Struct Biol. 2002 Jul;9(7):527-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12042876 12042876]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Takatsu, H.]]
[[Category: Takatsu, H.]]
[[Category: Wakatsuki, S.]]
[[Category: Wakatsuki, S.]]
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[[Category: coated pits]]
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[[Category: coated pit]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:15:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:54:54 2008''

Revision as of 09:54, 20 March 2008

Image:1iu1.jpg


PDB ID 1iu1

Drag the structure with the mouse to rotate
, resolution 1.80Å
Coordinates: save as pdb, mmCIF, xml



Crystal structure of human gamma1-adaptin ear domain


Overview

The adaptor proteins AP-1 and GGA regulate membrane traffic between the trans-Golgi network (TGN) and endosomes/lysosomes through ARF-regulated membrane association, recognition of sorting signals, and recruitment of clathrin and accessory proteins. The gamma 1-adaptin subunits of AP-1 and GGA possess homologous ear domains involved in the recruitment of accessory proteins, gamma-synergin and Rabaptin-5. The crystal structure of the human gamma 1-adaptin ear domain consists solely of an immunoglobulin-like fold, unlike the alpha-adaptin ear domain. Structure-based mutational analyses reveal a binding site for the accessory proteins that is composed of conserved basic residues, indicating that the recruitment mechanism in gamma 1-adaptin and GGA is distinct from that in alpha-adaptin.

About this Structure

1IU1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain., Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S, Nat Struct Biol. 2002 Jul;9(7):527-31. PMID:12042876

Page seeded by OCA on Thu Mar 20 11:54:54 2008

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