1ivv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ivv.jpg|left|200px]]<br /><applet load="1ivv" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1ivv.jpg|left|200px]]
-
caption="1ivv, resolution 2.1&Aring;" />
+
 
-
'''Crystal structure of copper amine oxidase from Arthrobacter globiformis: Early intermediate in topaquinone biogenesis'''<br />
+
{{Structure
 +
|PDB= 1ivv |SIZE=350|CAPTION= <scene name='initialview01'>1ivv</scene>, resolution 2.1&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=CU:COPPER (II) ION'>CU</scene>
 +
|ACTIVITY= [http://en.wikipedia.org/wiki/Amine_oxidase_(copper-containing) Amine oxidase (copper-containing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.6 1.4.3.6]
 +
|GENE=
 +
}}
 +
 
 +
'''Crystal structure of copper amine oxidase from Arthrobacter globiformis: Early intermediate in topaquinone biogenesis'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1IVV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arthrobacter_globiformis Arthrobacter globiformis] with <scene name='pdbligand=CU:'>CU</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Amine_oxidase_(copper-containing) Amine oxidase (copper-containing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.6 1.4.3.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IVV OCA].
+
1IVV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arthrobacter_globiformis Arthrobacter globiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IVV OCA].
==Reference==
==Reference==
-
X-ray snapshots of quinone cofactor biogenesis in bacterial copper amine oxidase., Kim M, Okajima T, Kishishita S, Yoshimura M, Kawamori A, Tanizawa K, Yamaguchi H, Nat Struct Biol. 2002 Aug;9(8):591-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12134140 12134140]
+
X-ray snapshots of quinone cofactor biogenesis in bacterial copper amine oxidase., Kim M, Okajima T, Kishishita S, Yoshimura M, Kawamori A, Tanizawa K, Yamaguchi H, Nat Struct Biol. 2002 Aug;9(8):591-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12134140 12134140]
[[Category: Amine oxidase (copper-containing)]]
[[Category: Amine oxidase (copper-containing)]]
[[Category: Arthrobacter globiformis]]
[[Category: Arthrobacter globiformis]]
Line 32: Line 41:
[[Category: tpq]]
[[Category: tpq]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:16:10 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:55:34 2008''

Revision as of 09:55, 20 March 2008

Image:1ivv.jpg


PDB ID 1ivv

Drag the structure with the mouse to rotate
, resolution 2.1Å
Ligands:
Activity: Amine oxidase (copper-containing), with EC number 1.4.3.6
Coordinates: save as pdb, mmCIF, xml



Crystal structure of copper amine oxidase from Arthrobacter globiformis: Early intermediate in topaquinone biogenesis


Overview

The quinone cofactor TPQ in copper amine oxidase is generated by posttranslational modification of an active site tyrosine residue. Using X-ray crystallography, we have probed the copper-dependent autooxidation process of TPQ in the enzyme from Arthrobacter globiformis. Apo enzyme crystals were anaerobically soaked with copper; the structure determined from this crystal provides a view of the initial state: the unmodified tyrosine coordinated to the bound copper. Exposure of the copper-bound crystals to oxygen led to the formation of freeze-trapped intermediates; structural analyses indicate that these intermediates contain dihydroxyphenylalanine quinone and trihydroxyphenylalanine. These are the first visualized intermediates during TPQ biogenesis in copper amine oxidase.

About this Structure

1IVV is a Single protein structure of sequence from Arthrobacter globiformis. Full crystallographic information is available from OCA.

Reference

X-ray snapshots of quinone cofactor biogenesis in bacterial copper amine oxidase., Kim M, Okajima T, Kishishita S, Yoshimura M, Kawamori A, Tanizawa K, Yamaguchi H, Nat Struct Biol. 2002 Aug;9(8):591-6. PMID:12134140

Page seeded by OCA on Thu Mar 20 11:55:34 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ivv"
Personal tools