1iwg
From Proteopedia
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| - | [[Image:1iwg.jpg|left|200px]] | + | [[Image:1iwg.jpg|left|200px]] |
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| - | '''Crystal structure of Bacterial Multidrug Efflux transporter AcrB''' | + | {{Structure |
| + | |PDB= 1iwg |SIZE=350|CAPTION= <scene name='initialview01'>1iwg</scene>, resolution 3.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Crystal structure of Bacterial Multidrug Efflux transporter AcrB''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1IWG is a [ | + | 1IWG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IWG OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of bacterial multidrug efflux transporter AcrB., Murakami S, Nakashima R, Yamashita E, Yamaguchi A, Nature. 2002 Oct 10;419(6907):587-93. PMID:[http:// | + | Crystal structure of bacterial multidrug efflux transporter AcrB., Murakami S, Nakashima R, Yamashita E, Yamaguchi A, Nature. 2002 Oct 10;419(6907):587-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12374972 12374972] |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transporter]] | [[Category: transporter]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:55:49 2008'' |
Revision as of 09:55, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of Bacterial Multidrug Efflux transporter AcrB
Overview
AcrB is a major multidrug exporter in Escherichia coli. It cooperates with a membrane fusion protein, AcrA, and an outer membrane channel, TolC. We have determined the crystal structure of AcrB at 3.5 A resolution. Three AcrB protomers are organized as a homotrimer in the shape of a jellyfish. Each protomer is composed of a transmembrane region 50 A thick and a 70 A protruding headpiece. The top of the headpiece opens like a funnel, where TolC might directly dock into AcrB. A pore formed by three alpha-helices connects the funnel with a central cavity located at the bottom of the headpiece. The cavity has three vestibules at the side of the headpiece which lead into the periplasm. In the transmembrane region, each protomer has twelve transmembrane alpha-helices. The structure implies that substrates translocated from the cell interior through the transmembrane region and from the periplasm through the vestibules are collected in the central cavity and then actively transported through the pore into the TolC tunnel.
About this Structure
1IWG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structure of bacterial multidrug efflux transporter AcrB., Murakami S, Nakashima R, Yamashita E, Yamaguchi A, Nature. 2002 Oct 10;419(6907):587-93. PMID:12374972
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