1izn

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[[Image:1izn.gif|left|200px]]<br /><applet load="1izn" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1izn.gif|left|200px]]
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caption="1izn, resolution 2.1&Aring;" />
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'''Crystal Structure of Actin Filament Capping Protein CapZ'''<br />
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{{Structure
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|PDB= 1izn |SIZE=350|CAPTION= <scene name='initialview01'>1izn</scene>, resolution 2.1&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NO3:NITRATE ION'>NO3</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal Structure of Actin Filament Capping Protein CapZ'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1IZN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=NO3:'>NO3</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZN OCA].
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1IZN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZN OCA].
==Reference==
==Reference==
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Crystal structure of CapZ: structural basis for actin filament barbed end capping., Yamashita A, Maeda K, Maeda Y, EMBO J. 2003 Apr 1;22(7):1529-38. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12660160 12660160]
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Crystal structure of CapZ: structural basis for actin filament barbed end capping., Yamashita A, Maeda K, Maeda Y, EMBO J. 2003 Apr 1;22(7):1529-38. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12660160 12660160]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: heterodimer]]
[[Category: heterodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:17:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:57:04 2008''

Revision as of 09:57, 20 March 2008

Image:1izn.gif


PDB ID 1izn

Drag the structure with the mouse to rotate
, resolution 2.1Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Actin Filament Capping Protein CapZ


Overview

Capping protein, a heterodimeric protein composed of alpha and beta subunits, is a key cellular component regulating actin filament assembly and organization. It binds to the barbed ends of the filaments and works as a 'cap' by preventing the addition and loss of actin monomers at the end. Here we describe the crystal structure of the chicken sarcomeric capping protein CapZ at 2.1 A resolution. The structure shows a striking resemblance between the alpha and beta subunits, so that the entire molecule has a pseudo 2-fold rotational symmetry. CapZ has a pair of mobile extensions for actin binding, one of which also provides concomitant binding to another protein for the actin filament targeting. The mobile extensions probably form flexible links to the end of the actin filament with a pseudo 2(1) helical symmetry, enabling the docking of the two in a symmetry mismatch.

About this Structure

1IZN is a Protein complex structure of sequences from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Crystal structure of CapZ: structural basis for actin filament barbed end capping., Yamashita A, Maeda K, Maeda Y, EMBO J. 2003 Apr 1;22(7):1529-38. PMID:12660160

Page seeded by OCA on Thu Mar 20 11:57:04 2008

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