We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2bt4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 32: Line 32:
[[Category: shikimate pathway]]
[[Category: shikimate pathway]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:23:25 2007''
+
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:47:20 2007''

Revision as of 14:42, 30 October 2007

Image:2bt4.gif

2bt4, resolution 1.70Å

Drag the structure with the mouse to rotate

TYPE II DEHYDROQUINASE INHIBITOR COMPLEX

Overview

Selective inhibitors of type II dehydroquinase were rationally designed to, explore a second binding-pocket in the active-site. The molecular, modelling, synthesis, inhibition studies and crystal structure, determination are described.

About this Structure

2BT4 is a [Single protein] structure of sequence from [Streptomyces coelicolor] with PO4, CA2, TRS and GOL as [ligands]. Active as [3-dehydroquinate dehydratase], with EC number [4.2.1.10]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Rational design of new bifunctional inhibitors of type II dehydroquinase., Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2005 Sep 7;3(17):3102-4. Epub 2005 Aug 1. PMID:16106291

Page seeded by OCA on Tue Oct 30 16:47:20 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bt4"
Personal tools