4gi4

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'''Unreleased structure'''
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{{STRUCTURE_4gi4| PDB=4gi4 | SCENE= }}
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===tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor===
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The entry 4gi4 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
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Authors: Immekus, F., Klebe, G.
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==About this Structure==
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[[4gi4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_zm4_=_atcc_31821 Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GI4 OCA].
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Description: tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor
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[[Category: Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]]
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[[Category: Immekus, F.]]
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[[Category: Klebe, G.]]
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[[Category: Biosynthesis]]
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[[Category: Queuosine]]
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[[Category: Tim barrel glycosyltransferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Trna]]
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[[Category: Trna processing]]

Revision as of 10:56, 4 September 2013

Template:STRUCTURE 4gi4

tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor

Function

[TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

About this Structure

4gi4 is a 1 chain structure with sequence from Zymomonas mobilis subsp. mobilis zm4 = atcc 31821. Full crystallographic information is available from OCA.

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OCA

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