4ght

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'''Unreleased structure'''
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{{STRUCTURE_4ght| PDB=4ght | SCENE= }}
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===Crystal structure of EV71 3C proteinase in complex with AG7088===
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{{ABSTRACT_PUBMED_23633597}}
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The entry 4ght is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/A9XG43_9ENTO A9XG43_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
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Authors: Chen, C., Wu, C., Cai, Q., Li, N., Peng, X., Cai, Y., Yin, K., Chen, X., Wang, X., Zhang, R., Liu, L., Chen, S., Li, J., Lin, T.
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==About this Structure==
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[[4ght]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterovirus_a71 Enterovirus a71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GHT OCA].
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Description: Crystal structure of EV71 3C proteinase in complex with AG7088
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==Reference==
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<ref group="xtra">PMID:023633597</ref><references group="xtra"/><references/>
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[[Category: Enterovirus a71]]
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[[Category: Picornain 3C]]
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[[Category: Cai, Q.]]
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[[Category: Cai, Y.]]
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[[Category: Chen, C.]]
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[[Category: Chen, S.]]
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[[Category: Chen, X.]]
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[[Category: Li, J.]]
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[[Category: Li, N.]]
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[[Category: Lin, T.]]
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[[Category: Liu, L.]]
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[[Category: Peng, X.]]
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[[Category: Wang, X.]]
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[[Category: Wu, C.]]
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[[Category: Yin, K.]]
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[[Category: Zhang, R.]]
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[[Category: Cysteine proteinase]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitor]]

Revision as of 10:10, 30 June 2013

Template:STRUCTURE 4ght

Contents

Crystal structure of EV71 3C proteinase in complex with AG7088

Template:ABSTRACT PUBMED 23633597

Function

[A9XG43_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]

About this Structure

4ght is a 2 chain structure with sequence from Enterovirus a71. Full crystallographic information is available from OCA.

Reference

  • Wu C, Cai Q, Chen C, Li N, Peng X, Cai Y, Yin K, Chen X, Wang X, Zhang R, Liu L, Chen S, Li J, Lin T. Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir. Acta Crystallogr D Biol Crystallogr. 2013 May;69(Pt 5):866-71. doi:, 10.1107/S0907444913002862. Epub 2013 Apr 19. PMID:23633597 doi:10.1107/S0907444913002862

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