1jh5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1jh5.gif|left|200px]]<br /><applet load="1jh5" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1jh5.gif|left|200px]]
-
caption="1jh5, resolution 3.00&Aring;" />
+
 
-
'''Crystal Structure of sTALL-1 of TNF family ligand'''<br />
+
{{Structure
 +
|PDB= 1jh5 |SIZE=350|CAPTION= <scene name='initialview01'>1jh5</scene>, resolution 3.00&Aring;
 +
|SITE=
 +
|LIGAND=
 +
|ACTIVITY=
 +
|GENE=
 +
}}
 +
 
 +
'''Crystal Structure of sTALL-1 of TNF family ligand'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1JH5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JH5 OCA].
+
1JH5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JH5 OCA].
==Reference==
==Reference==
-
Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands., Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G, Cell. 2002 Feb 8;108(3):383-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11853672 11853672]
+
Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands., Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G, Cell. 2002 Feb 8;108(3):383-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11853672 11853672]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 19: Line 28:
[[Category: Zhang, G.]]
[[Category: Zhang, G.]]
[[Category: baff]]
[[Category: baff]]
-
[[Category: blys]]
+
[[Category: bly]]
[[Category: tall-1]]
[[Category: tall-1]]
[[Category: thank]]
[[Category: thank]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:22:33 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:03:19 2008''

Revision as of 10:03, 20 March 2008

Image:1jh5.gif


PDB ID 1jh5

Drag the structure with the mouse to rotate
, resolution 3.00Å
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of sTALL-1 of TNF family ligand


Overview

TALL-1/BAFF/BLyS was recently identified as a member of the tumor necrosis factor (TNF) ligand family. The crystal structure of the functional soluble TALL-1 (sTALL-1) has been determined at 3.0 A. sTALL-1 forms a virus-like assembly with 200 A diameter in the crystals, containing 60 sTALL-1 monomers. The cluster formation is mediated by a "flap" region of the sTALL-1 monomer. The virus-like assembly was also detected in solution using gel filtration and electron microscopy. Deletion of the flap region disrupted the formation of the virus-like assembly. The mutant sTALL-1 still bound its receptor but could not activate NF-kappaB and did not stimulate B lymphocyte proliferation. Finally, we found the virus-like cluster of sTALL-1 exists in physiological condition. We propose that this virus-like assembly of sTALL-1 is the functional unit for TALL-1 in vivo.

About this Structure

1JH5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands., Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G, Cell. 2002 Feb 8;108(3):383-94. PMID:11853672

Page seeded by OCA on Thu Mar 20 12:03:19 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jh5"
Personal tools