1ji5
From Proteopedia
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| - | [[Image:1ji5.jpg|left|200px]] | + | [[Image:1ji5.jpg|left|200px]] |
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| - | '''Dlp-1 from bacillus anthracis''' | + | {{Structure |
| + | |PDB= 1ji5 |SIZE=350|CAPTION= <scene name='initialview01'>1ji5</scene>, resolution 2.50Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= dlp-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis]) | ||
| + | }} | ||
| + | |||
| + | '''Dlp-1 from bacillus anthracis''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1JI5 is a [ | + | 1JI5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI5 OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of two iron-binding proteins from Bacillus anthracis., Papinutto E, Dundon WG, Pitulis N, Battistutta R, Montecucco C, Zanotti G, J Biol Chem. 2002 Apr 26;277(17):15093-8. Epub 2002 Feb 8. PMID:[http:// | + | Structure of two iron-binding proteins from Bacillus anthracis., Papinutto E, Dundon WG, Pitulis N, Battistutta R, Montecucco C, Zanotti G, J Biol Chem. 2002 Apr 26;277(17):15093-8. Epub 2002 Feb 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11836250 11836250] |
[[Category: Bacillus anthracis]] | [[Category: Bacillus anthracis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: four-helix bundle]] | [[Category: four-helix bundle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:03:44 2008'' |
Revision as of 10:03, 20 March 2008
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| , resolution 2.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Gene: | dlp-1 (Bacillus anthracis) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Dlp-1 from bacillus anthracis
Overview
Bacillus anthracis is currently under intense investigation due to its primary importance as a human pathogen. Particularly important is the development of novel anti-anthrax vaccines, devoid of the current side effects. A novel class of immunogenic bacterial proteins consists of dodecamers homologous to the DNA-binding protein of Escherichia coli (Dps). Two Dps homologous genes are present in the B. anthracis genome. The crystal structures of these two proteins (Dlp-1 and Dlp-2) have been determined and are presented here. They are sphere-like proteins with an internal cavity. We also show that they act as ferritins and are thus involved in iron uptake and regulation, a fundamental function during bacterial growth.
About this Structure
1JI5 is a Single protein structure of sequence from Bacillus anthracis. Full crystallographic information is available from OCA.
Reference
Structure of two iron-binding proteins from Bacillus anthracis., Papinutto E, Dundon WG, Pitulis N, Battistutta R, Montecucco C, Zanotti G, J Biol Chem. 2002 Apr 26;277(17):15093-8. Epub 2002 Feb 8. PMID:11836250
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