1ji4
From Proteopedia
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| - | [[Image:1ji4.gif|left|200px]] | + | [[Image:1ji4.gif|left|200px]] |
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| - | '''NAP protein from helicobacter pylori''' | + | {{Structure |
| + | |PDB= 1ji4 |SIZE=350|CAPTION= <scene name='initialview01'>1ji4</scene>, resolution 2.52Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= NAPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori]) | ||
| + | }} | ||
| + | |||
| + | '''NAP protein from helicobacter pylori''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1JI4 is a [ | + | 1JI4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI4 OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the neutrophil-activating protein from Helicobacter pylori., Zanotti G, Papinutto E, Dundon W, Battistutta R, Seveso M, Giudice G, Rappuoli R, Montecucco C, J Mol Biol. 2002 Oct 11;323(1):125-30. PMID:[http:// | + | Structure of the neutrophil-activating protein from Helicobacter pylori., Zanotti G, Papinutto E, Dundon W, Battistutta R, Seveso M, Giudice G, Rappuoli R, Montecucco C, J Mol Biol. 2002 Oct 11;323(1):125-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12368104 12368104] |
[[Category: Helicobacter pylori]] | [[Category: Helicobacter pylori]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: four-helix bundle]] | [[Category: four-helix bundle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:03:42 2008'' |
Revision as of 10:03, 20 March 2008
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| , resolution 2.52Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , and | ||||||
| Gene: | NAPA (Helicobacter pylori) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NAP protein from helicobacter pylori
Overview
Helicobacter pylori is a major human pathogen associated with severe gastroduodenal diseases, including ulcers and cancers. An H.pylori protein that is highly immunogenic in humans and mice has been identified recently. This protein has been termed HP-NAP, due to its ability of activating neutrophils. In order to achieve a molecular understanding of its unique immunogenic and pro-inflammatory properties, we have determined its three-dimensional structure. Its quaternary structure is similar to that of the dodecameric bacterial ferritins (Dps-like family), but it has a different surface potential charge distribution. This is due to the presence of a large number of positively charged residues, which could well account for its unique ability in activating human leukocytes.
About this Structure
1JI4 is a Single protein structure of sequence from Helicobacter pylori. Full crystallographic information is available from OCA.
Reference
Structure of the neutrophil-activating protein from Helicobacter pylori., Zanotti G, Papinutto E, Dundon W, Battistutta R, Seveso M, Giudice G, Rappuoli R, Montecucco C, J Mol Biol. 2002 Oct 11;323(1):125-30. PMID:12368104
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