1jig

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[[Image:1jig.jpg|left|200px]]<br /><applet load="1jig" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1jig.jpg|left|200px]]
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caption="1jig, resolution 1.46&Aring;" />
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'''Dlp-2 from Bacillus anthracis'''<br />
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{{Structure
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|PDB= 1jig |SIZE=350|CAPTION= <scene name='initialview01'>1jig</scene>, resolution 1.46&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=FE:FE (III) ION'>FE</scene>
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|ACTIVITY=
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|GENE= dlp-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])
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}}
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'''Dlp-2 from Bacillus anthracis'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1JIG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] with <scene name='pdbligand=FE:'>FE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JIG OCA].
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1JIG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JIG OCA].
==Reference==
==Reference==
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Structure of two iron-binding proteins from Bacillus anthracis., Papinutto E, Dundon WG, Pitulis N, Battistutta R, Montecucco C, Zanotti G, J Biol Chem. 2002 Apr 26;277(17):15093-8. Epub 2002 Feb 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11836250 11836250]
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Structure of two iron-binding proteins from Bacillus anthracis., Papinutto E, Dundon WG, Pitulis N, Battistutta R, Montecucco C, Zanotti G, J Biol Chem. 2002 Apr 26;277(17):15093-8. Epub 2002 Feb 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11836250 11836250]
[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: four-helix bundle]]
[[Category: four-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:22:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:03:53 2008''

Revision as of 10:03, 20 March 2008

Image:1jig.jpg


PDB ID 1jig

Drag the structure with the mouse to rotate
, resolution 1.46Å
Ligands:
Gene: dlp-2 (Bacillus anthracis)
Coordinates: save as pdb, mmCIF, xml



Dlp-2 from Bacillus anthracis


Overview

Bacillus anthracis is currently under intense investigation due to its primary importance as a human pathogen. Particularly important is the development of novel anti-anthrax vaccines, devoid of the current side effects. A novel class of immunogenic bacterial proteins consists of dodecamers homologous to the DNA-binding protein of Escherichia coli (Dps). Two Dps homologous genes are present in the B. anthracis genome. The crystal structures of these two proteins (Dlp-1 and Dlp-2) have been determined and are presented here. They are sphere-like proteins with an internal cavity. We also show that they act as ferritins and are thus involved in iron uptake and regulation, a fundamental function during bacterial growth.

About this Structure

1JIG is a Single protein structure of sequence from Bacillus anthracis. Full crystallographic information is available from OCA.

Reference

Structure of two iron-binding proteins from Bacillus anthracis., Papinutto E, Dundon WG, Pitulis N, Battistutta R, Montecucco C, Zanotti G, J Biol Chem. 2002 Apr 26;277(17):15093-8. Epub 2002 Feb 8. PMID:11836250

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