1jn2

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[[Image:1jn2.jpg|left|200px]]<br /><applet load="1jn2" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1jn2.jpg|left|200px]]
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caption="1jn2, resolution 1.9&Aring;" />
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'''Crystal Structure of meso-tetrasulphonatophenyl porphyrin complexed with Concanavalin A'''<br />
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{{Structure
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|PDB= 1jn2 |SIZE=350|CAPTION= <scene name='initialview01'>1jn2</scene>, resolution 1.9&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene> and <scene name='pdbligand=SFP:5,10,15,20-TETRAKIS(4-SULPFONATOPHENYL)-21H,23H-PORPHINE'>SFP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal Structure of meso-tetrasulphonatophenyl porphyrin complexed with Concanavalin A'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1JN2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=MN:'>MN</scene> and <scene name='pdbligand=SFP:'>SFP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JN2 OCA].
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1JN2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JN2 OCA].
==Reference==
==Reference==
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Functional equality in the absence of structural similarity: an added dimension to molecular mimicry., Goel M, Jain D, Kaur KJ, Kenoth R, Maiya BG, Swamy MJ, Salunke DM, J Biol Chem. 2001 Oct 19;276(42):39277-81. Epub 2001 Aug 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11504727 11504727]
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Functional equality in the absence of structural similarity: an added dimension to molecular mimicry., Goel M, Jain D, Kaur KJ, Kenoth R, Maiya BG, Swamy MJ, Salunke DM, J Biol Chem. 2001 Oct 19;276(42):39277-81. Epub 2001 Aug 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11504727 11504727]
[[Category: Canavalia ensiformis]]
[[Category: Canavalia ensiformis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: lectin]]
[[Category: lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:24:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:05:41 2008''

Revision as of 10:05, 20 March 2008

Image:1jn2.jpg


PDB ID 1jn2

Drag the structure with the mouse to rotate
, resolution 1.9Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of meso-tetrasulphonatophenyl porphyrin complexed with Concanavalin A


Overview

The crystal structure of meso-tetrasulfonatophenylporphyrin complexed with concanavalin A (ConA) was determined at 1.9 A resolution. Comparison of this structure with that of ConA bound to methyl alpha-d-mannopyranoside provided direct structural evidence of molecular mimicry in the context of ligand receptor binding. The sulfonatophenyl group of meso-tetrasulfonatophenylporphyrin occupies the same binding site on ConA as that of methyl alpha-d-mannopyranoside, a natural ligand. A pair of stacked porphyrin molecules stabilizes the crystal structure by end-to-end cross-linking with ConA resulting in a network similar to that observed upon agglutination of cells by lectins. The porphyrin binds to ConA predominantly through hydrogen bonds and water-mediated interactions. The sandwiched water molecules in the complex play a cementing role, facilitating favorable binding of porphyrin. Seven of the eight hydrogen bonds observed between methyl alpha-d-mannopyranoside and ConA are mimicked by the sulfonatophenyl group of porphyrin after incorporating two water molecules. Thus, the similarity in chemical interactions was manifested in terms of functional mimicry despite the obvious structural dissimilarity between the sugar and the porphyrin.

About this Structure

1JN2 is a Single protein structure of sequence from Canavalia ensiformis. Full crystallographic information is available from OCA.

Reference

Functional equality in the absence of structural similarity: an added dimension to molecular mimicry., Goel M, Jain D, Kaur KJ, Kenoth R, Maiya BG, Swamy MJ, Salunke DM, J Biol Chem. 2001 Oct 19;276(42):39277-81. Epub 2001 Aug 14. PMID:11504727

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