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Sandbox pia
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== Structural model of yeast 26S == | == Structural model of yeast 26S == | ||
| - | <StructureSection load='4b4t' size='350' side='right' caption='Structural model of yeast 26S (PDB entry [[4b4t]])' scene=''> | + | <StructureSection load='4b4t' size='350' side='right' caption='Structural model of yeast 26S (PDB entry [[4b4t]])' scene='Sandbox_pia/26s_color/1'> |
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The model displays one half of the symmetric 26S proteasome. The complex consists of a core particle, build out of 4 heptameric rings in the order <math> {/alpha} </math> - <math> /beta </math> - <math>/beta</math> - <math>/alpha</math> | The model displays one half of the symmetric 26S proteasome. The complex consists of a core particle, build out of 4 heptameric rings in the order <math> {/alpha} </math> - <math> /beta </math> - <math>/beta</math> - <math>/alpha</math> | ||
The regulatory particle is divided into a base and a lid. The base are 6 AAA-ATPases (Rpt1-6), Rpn1 whereas the lid consists of non-ATPases containing a PCI domain( Rpn9,5 6 73 12), a <scene name='Sandbox_pia/Mpn/2'>MPN</scene> domain (Rpn8, 11), Ubiquitin receptors (Rpn10 13) | The regulatory particle is divided into a base and a lid. The base are 6 AAA-ATPases (Rpt1-6), Rpn1 whereas the lid consists of non-ATPases containing a PCI domain( Rpn9,5 6 73 12), a <scene name='Sandbox_pia/Mpn/2'>MPN</scene> domain (Rpn8, 11), Ubiquitin receptors (Rpn10 13) | ||
| - | <scene name='Sandbox_pia/26s_color/1'> | + | <scene name='Sandbox_pia/26s_color/1'>26S</scene> |
| + | The C-termini (like the <scene name='Sandbox_pia/Rpt2_ter/2'>Rpt2 C-Terminus</scene>) of some ATPases can be localized in pockets between the alpha subunits and play a role in gate opeing, as suggested by <ref> pmid </ref> | ||
As described before: <ref>pmid 22307589</ref> <ref>pmid 20467039 </ref> | As described before: <ref>pmid 22307589</ref> <ref>pmid 20467039 </ref> | ||
Revision as of 09:26, 6 September 2012
Structural model of yeast 26S
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- ↑ . PMID:216315890657
- ↑ Lasker K, Forster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W. Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1380-7. Epub 2012 Jan 23. PMID:22307589 doi:10.1073/pnas.1120559109
- ↑ Forster F, Lasker K, Nickell S, Sali A, Baumeister W. Toward an integrated structural model of the 26S proteasome. Mol Cell Proteomics. 2010 Aug;9(8):1666-77. Epub 2010 May 13. PMID:20467039 doi:10.1074/mcp.R000002-MCP201
