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Nuclear receptor

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The structure of the LBD is strongly conserved throughout the familly of nuclear receptors.
The structure of the LBD is strongly conserved throughout the familly of nuclear receptors.
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It is a globular domain
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It is a globular domain, mainly alpha
<scene name='Nuclear_receptor/Nr-lbd-/1'>well folded</scene>
<scene name='Nuclear_receptor/Nr-lbd-/1'>well folded</scene>
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and composed of 12 alpha-helices arranged in a three layered sandwich, and a <scene name='Nuclear_receptor/Nr-lbd-beta/1'>beta-sheet</scene>.
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composed of
 +
<scene name='Nuclear_receptor/Nr-lbd-alpha/1'>12 alpha-helices</scene>
 +
arranged in a three layered sandwich, and a <scene name='Nuclear_receptor/Nr-lbd-beta/1'>beta-sheet</scene>.
</StructureSection>
</StructureSection>
<references/>
<references/>

Revision as of 10:41, 6 September 2012

the nuclear receptors facts book [1]

Structure

DBD (DNA Binding Domain)

LBD (Ligand Binding Domain)

Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry 1ie8)

Drag the structure with the mouse to rotate
  1. ↑ Vincent Laudet, Hinrich Gronemeyer, "The nuclear receptor factsbook", Publisher Academic Press, 2002

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Alexander Berchansky, Schwarz Benjamin

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