This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4fzb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4fzb| PDB=4fzb | SCENE= }}
 +
===Structure of thymidylate synthase ThyX complexed to a new inhibitor===
 +
{{ABSTRACT_PUBMED_23155486}}
-
The entry 4fzb is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/THYX_PBCV1 THYX_PBCV1]] Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity).
-
Authors: Basta, T., Boum, Y., Briffotaux, J., Becker, H.F., Lamarre-Jouenne, I., Lambry, J.C., Skouloubris, S., Liebl, U., van Tilbeurgh, H., Graille, M., Myllylkallio, H.
+
==About this Structure==
 +
[[4fzb]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Paramecium_bursaria_chlorella_virus_1 Paramecium bursaria chlorella virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZB OCA].
-
Description: Enzyme-inhibitor complex
+
==Reference==
 +
<ref group="xtra">PMID:023155486</ref><references group="xtra"/><references/>
 +
[[Category: Paramecium bursaria chlorella virus 1]]
 +
[[Category: Basta, T.]]
 +
[[Category: Becker, H F.]]
 +
[[Category: Boum, Y.]]
 +
[[Category: Briffotaux, J.]]
 +
[[Category: Graille, M.]]
 +
[[Category: Lamarre-Jouenne, I.]]
 +
[[Category: Lambry, J C.]]
 +
[[Category: Liebl, U.]]
 +
[[Category: Myllylkallio, H.]]
 +
[[Category: Skouloubris, S.]]
 +
[[Category: Tilbeurgh, H van.]]
 +
[[Category: Fad-dependent thymidylate synthase]]
 +
[[Category: Homotetramer]]
 +
[[Category: Transferase-transferase inhibitor complex]]

Revision as of 15:38, 19 June 2013

Template:STRUCTURE 4fzb

Contents

Structure of thymidylate synthase ThyX complexed to a new inhibitor

Template:ABSTRACT PUBMED 23155486

Function

[THYX_PBCV1] Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity).

About this Structure

4fzb is a 16 chain structure with sequence from Paramecium bursaria chlorella virus 1. Full crystallographic information is available from OCA.

Reference

  • Basta T, Boum Y, Briffotaux J, Becker HF, Lamarre-Jouenne I, Lambry JC, Skouloubris S, Liebl U, Graille M, van Tilbeurgh H, Myllykallio H. Mechanistic and structural basis for inhibition of thymidylate synthase ThyX. Open Biol. 2012 Oct;2(10):120120. doi: 10.1098/rsob.120120. PMID:23155486 doi:10.1098/rsob.120120

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4fzb"
Personal tools