4gn7

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'''Unreleased structure'''
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{{STRUCTURE_4gn7| PDB=4gn7 | SCENE= }}
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===mouse SMP30/GNL===
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{{ABSTRACT_PUBMED_23349732}}
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The entry 4gn7 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/RGN_MOUSE RGN_MOUSE]] Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).<ref>PMID:16585534</ref>
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Authors: Aizawa, S., Senda, M., Harada, A., Maruyama, N., Ishida, T., Aigaki, T., Ishigami, A., Senda, T.
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==About this Structure==
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[[4gn7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GN7 OCA].
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Description: mouse SMP30/GNL
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Gluconolactonase]]
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[[Category: Mus musculus]]
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[[Category: Aigaki, T.]]
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[[Category: Aizawa, S.]]
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[[Category: Harada, A.]]
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[[Category: Ishida, T.]]
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[[Category: Ishigami, A.]]
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[[Category: Maruyama, N.]]
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[[Category: Senda, M.]]
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[[Category: Senda, T.]]
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[[Category: Beta propeller structure]]
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[[Category: Hydrolase]]

Revision as of 22:43, 10 April 2013

Template:STRUCTURE 4gn7

Contents

mouse SMP30/GNL

Template:ABSTRACT PUBMED 23349732

Function

[RGN_MOUSE] Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).[1]

About this Structure

4gn7 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Kondo Y, Inai Y, Sato Y, Handa S, Kubo S, Shimokado K, Goto S, Nishikimi M, Maruyama N, Ishigami A. Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5723-8. Epub 2006 Apr 3. PMID:16585534 doi:10.1073/pnas.0511225103

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OCA

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