1jsd

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[[Image:1jsd.gif|left|200px]]<br /><applet load="1jsd" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1jsd.gif|left|200px]]
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caption="1jsd, resolution 1.8&Aring;" />
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'''CRYSTAL STRUCTURE OF SWINE H9 HAEMAGGLUTININ'''<br />
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{{Structure
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|PDB= 1jsd |SIZE=350|CAPTION= <scene name='initialview01'>1jsd</scene>, resolution 1.8&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF SWINE H9 HAEMAGGLUTININ'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1JSD is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSD OCA].
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1JSD is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSD OCA].
==Reference==
==Reference==
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H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes., Ha Y, Stevens DJ, Skehel JJ, Wiley DC, EMBO J. 2002 Mar 1;21(5):865-75. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11867515 11867515]
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H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes., Ha Y, Stevens DJ, Skehel JJ, Wiley DC, EMBO J. 2002 Mar 1;21(5):865-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11867515 11867515]
[[Category: Influenza a virus]]
[[Category: Influenza a virus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: influenza]]
[[Category: influenza]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:26:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:07:47 2008''

Revision as of 10:07, 20 March 2008

Image:1jsd.gif


PDB ID 1jsd

Drag the structure with the mouse to rotate
, resolution 1.8Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF SWINE H9 HAEMAGGLUTININ


Overview

There are 15 subtypes of influenza A virus (H1-H15), all of which are found in avian species. Three caused pandemics in the last century: H1 in 1918 (and 1977), H2 in 1957 and H3 in 1968. In 1997, an H5 avian virus and in 1999 an H9 virus caused outbreaks of respiratory disease in Hong Kong. We have determined the three-dimensional structures of the haemagglutinins (HAs) from H5 avian and H9 swine viruses closely related to the viruses isolated from humans in Hong Kong. We have compared them with known structures of the H3 HA from the virus that caused the 1968 H3 pandemic and of the HA--esterase--fusion (HEF) glycoprotein from an influenza C virus. Structure and sequence comparisons suggest that HA subtypes may have originated by diversification of properties that affected the metastability of HAs required for their membrane fusion activities in viral infection.

About this Structure

1JSD is a Protein complex structure of sequences from Influenza a virus. Full crystallographic information is available from OCA.

Reference

H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes., Ha Y, Stevens DJ, Skehel JJ, Wiley DC, EMBO J. 2002 Mar 1;21(5):865-75. PMID:11867515

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