4guo

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'''Unreleased structure'''
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{{STRUCTURE_4guo| PDB=4guo | SCENE= }}
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===structure of p73 DNA binding domain complex with 12 bp DNA===
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The entry 4guo is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>
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Authors: Ethayathulla, A.S, Viadiu, H.
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==About this Structure==
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[[4guo]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUO OCA].
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Description: structure of p73 DNA binding domain complex with 12 bp DNA
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Ethayathulla, A S]]
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[[Category: Viadiu, H.]]
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[[Category: Beta-immunoglobulin fold]]
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[[Category: Dna]]
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[[Category: Dna binding]]
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[[Category: Transcription factor]]
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[[Category: Transcription-dna complex]]
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[[Category: Tumor suppressor]]

Revision as of 10:29, 27 November 2013

Template:STRUCTURE 4guo

Contents

structure of p73 DNA binding domain complex with 12 bp DNA

Function

[P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.[1] [2] [3]

About this Structure

4guo is a 16 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Grob TJ, Novak U, Maisse C, Barcaroli D, Luthi AU, Pirnia F, Hugli B, Graber HU, De Laurenzi V, Fey MF, Melino G, Tobler A. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ. 2001 Dec;8(12):1213-23. PMID:11753569 doi:10.1038/sj.cdd.4400962
  2. ↑ Kaelin WG Jr. The emerging p53 gene family. J Natl Cancer Inst. 1999 Apr 7;91(7):594-8. PMID:10203277
  3. ↑ Koida N, Ozaki T, Yamamoto H, Ono S, Koda T, Ando K, Okoshi R, Kamijo T, Omura K, Nakagawara A. Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. J Biol Chem. 2008 Mar 28;283(13):8555-63. doi: 10.1074/jbc.M710608200. Epub 2008 , Jan 3. PMID:18174154 doi:10.1074/jbc.M710608200

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