1js3
From Proteopedia
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| - | [[Image:1js3.gif|left|200px]] | + | [[Image:1js3.gif|left|200px]] |
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| - | '''Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa''' | + | {{Structure |
| + | |PDB= 1js3 |SIZE=350|CAPTION= <scene name='initialview01'>1js3</scene>, resolution 2.25Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5'-PHOSPHATE'>PLP</scene> and <scene name='pdbligand=142:CARBIDOPA'>142</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Aromatic-L-amino-acid_decarboxylase Aromatic-L-amino-acid decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.28 4.1.1.28] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1JS3 is a [ | + | 1JS3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS3 OCA]. |
==Reference== | ==Reference== | ||
| - | Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase., Burkhard P, Dominici P, Borri-Voltattorni C, Jansonius JN, Malashkevich VN, Nat Struct Biol. 2001 Nov;8(11):963-7. PMID:[http:// | + | Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase., Burkhard P, Dominici P, Borri-Voltattorni C, Jansonius JN, Malashkevich VN, Nat Struct Biol. 2001 Nov;8(11):963-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11685243 11685243] |
[[Category: Aromatic-L-amino-acid decarboxylase]] | [[Category: Aromatic-L-amino-acid decarboxylase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: vitamin b6]] | [[Category: vitamin b6]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:07:41 2008'' |
Revision as of 10:07, 20 March 2008
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| , resolution 2.25Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , and | ||||||
| Activity: | Aromatic-L-amino-acid decarboxylase, with EC number 4.1.1.28 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa
Overview
DOPA decarboxylase (DDC) is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan, respectively. DDC has been implicated in a number of clinic disorders, including Parkinson's disease and hypertension. Peripheral inhibitors of DDC are currently used to treat these diseases. We present the crystal structures of ligand-free DDC and its complex with the anti-Parkinson drug carbiDOPA. The inhibitor is bound to the enzyme by forming a hydrazone linkage with the cofactor, and its catechol ring is deeply buried in the active site cleft. The structures provide the molecular basis for the development of new inhibitors of DDC with better pharmacological characteristics.
About this Structure
1JS3 is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.
Reference
Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase., Burkhard P, Dominici P, Borri-Voltattorni C, Jansonius JN, Malashkevich VN, Nat Struct Biol. 2001 Nov;8(11):963-7. PMID:11685243
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