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1jsu

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[[Image:1jsu.gif|left|200px]]<br /><applet load="1jsu" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1jsu.gif|left|200px]]
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caption="1jsu, resolution 2.3&Aring;" />
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'''P27(KIP1)/CYCLIN A/CDK2 COMPLEX'''<br />
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{{Structure
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|PDB= 1jsu |SIZE=350|CAPTION= <scene name='initialview01'>1jsu</scene>, resolution 2.3&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''P27(KIP1)/CYCLIN A/CDK2 COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1JSU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSU OCA].
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1JSU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSU OCA].
==Reference==
==Reference==
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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex., Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP, Nature. 1996 Jul 25;382(6589):325-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8684460 8684460]
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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex., Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP, Nature. 1996 Jul 25;382(6589):325-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8684460 8684460]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: kinase]]
[[Category: kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:26:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:07:59 2008''

Revision as of 10:08, 20 March 2008

Image:1jsu.gif


PDB ID 1jsu

Drag the structure with the mouse to rotate
, resolution 2.3Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



P27(KIP1)/CYCLIN A/CDK2 COMPLEX


Contents

Overview

The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by conserved cyclin box residues. On Cdk2, it binds and rearranges the amino-terminal lobe and also inserts into the catalytic cleft, mimicking ATP.

Disease

Known diseases associated with this structure: Multiple endocrine neoplasia, type IV OMIM:[600778]

About this Structure

1JSU is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex., Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP, Nature. 1996 Jul 25;382(6589):325-31. PMID:8684460

Page seeded by OCA on Thu Mar 20 12:07:59 2008

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