1jty
From Proteopedia
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| - | [[Image:1jty.gif|left|200px]] | + | [[Image:1jty.gif|left|200px]] |
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| - | '''Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium''' | + | {{Structure |
| + | |PDB= 1jty |SIZE=350|CAPTION= <scene name='initialview01'>1jty</scene>, resolution 2.97Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ET:ETHIDIUM'>ET</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1JTY is a [ | + | 1JTY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTY OCA]. |
==Reference== | ==Reference== | ||
| - | Structural mechanisms of QacR induction and multidrug recognition., Schumacher MA, Miller MC, Grkovic S, Brown MH, Skurray RA, Brennan RG, Science. 2001 Dec 7;294(5549):2158-63. PMID:[http:// | + | Structural mechanisms of QacR induction and multidrug recognition., Schumacher MA, Miller MC, Grkovic S, Brown MH, Skurray RA, Brennan RG, Science. 2001 Dec 7;294(5549):2158-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11739955 11739955] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
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[[Category: ET]] | [[Category: ET]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
| - | [[Category: cationic lipophilic | + | [[Category: cationic lipophilic drug]] |
[[Category: multidrug binding]] | [[Category: multidrug binding]] | ||
[[Category: multidrug recognition mechanism]] | [[Category: multidrug recognition mechanism]] | ||
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[[Category: transcription]] | [[Category: transcription]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:08:27 2008'' |
Revision as of 10:08, 20 March 2008
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| , resolution 2.97Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium
Overview
The Staphylococcus aureus multidrug binding protein QacR represses transcription of the qacA multidrug transporter gene and is induced by structurally diverse cationic lipophilic drugs. Here, we report the crystal structures of six QacR-drug complexes. Compared to the DNA bound structure, drug binding elicits a coil-to-helix transition that causes induction and creates an expansive multidrug-binding pocket, containing four glutamates and multiple aromatic and polar residues. These structures indicate the presence of separate but linked drug-binding sites within a single protein. This multisite drug-binding mechanism is consonant with studies on multidrug resistance transporters.
About this Structure
1JTY is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Structural mechanisms of QacR induction and multidrug recognition., Schumacher MA, Miller MC, Grkovic S, Brown MH, Skurray RA, Brennan RG, Science. 2001 Dec 7;294(5549):2158-63. PMID:11739955
Page seeded by OCA on Thu Mar 20 12:08:27 2008
